Tsung-Yu Chen

Tsung-Yu Chen

Position Title

Department of Neurology, School of Medicine
Center for Neuroscience

1544 Newton Court, Davis, CA

Profile Introduction

Structures, functions and physiological roles of ion channels.

Research Interests

Structures, functions and physiological roles of ion channels and transporters.

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Biophysics
  • Molecular, Cellular and Integrative Physiology
  • Neuroscience
  • Pharmacology and Toxicology (PTX)

Specialties / Focus

  • Cellular Physiology
  • Molecular Medicine
  • Molecular Physiology
  • Molecular Physiology
  • Neurobiology
  • Organelle and Membrane Biology
  • Signaling and Excitable Membranes
  • Structural Biology


  • NSC 221 Cellular Neuroscience, Fall


  • Chen Lab http://neuroscience.ucdavis.edu/user/15
    • Yawei Yu, Wei-Ping Yu, Ji-Peng Chen

Honors and Awards

  • Paul Cranefield Award, Society of General Physiologists, 2004.

    Professional Societies

    • Biophysical Society, USA
    • Society of General Physiologists, USA


    • 1986 MD National Yang-Ming Medical College
    • 1988 MS National Yang-Ming Medical College
    • 1994 PhD Johns Hopkins University School of Medicine


    Nguyen D.M., Chen L.S., Yu W.-P., and Chen T.-Y. (2019) Comparison of ion transport determinants between a TMEM16 chloride channel and phospholipid scramblase. J. Gen. Physiol. 151: 518-531.

    Jeng G., Aggarwal M., Yu W.-P., and Chen T.-Y. (2016) Independent activation of distinct pores in dimeric TMEM16A channels. J. Gen. Physiol. 148:393-404. 

    Yu Y., Tsai M.-F., Yu W.-P., and Chen T.-Y. (2015) Modulation of the slow/common gating of CLC Channels by Intracellular cadmium. J. Gen. Physiol. 146: 495-508.

    Yu Y., Kuan A-S, and Chen T-Y (2014) Calcium-calmodulin does not alter the anion permeability of the mouse TMEM16A calcium-activated chloride channel. J. Gen. Physiol. 144:115-124.

    Bennetts B, Yu Y, Chen T-Y, and Parker MW (2012) Intracellular beta-nicotinamide adenine dinucleotide inhibits the skeletal muscle ClC-1 chloride channel. J. Biol. Chen. 287: 25808-25820.

    Richman DP, Yu Y, Lee T-T, Tseng P-Y, Yu W-P, Maselli RA, Tang C-Y and Chen T-Y (2012) Dominantly-inherited myotonia congenita resulting from a mutation that increases open probability of the muscle chloride channel CLC-1. Neuromol. Med. 14:328-337.

    Tang C.-Y., and Chen T.-Y. (2011) Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia. Journal of Biomedicine and Biotechnology: Vol2011, Article ID 685328, 2011. doi:10.1155/2011/685328.

    Zhang X.-D., Tseng P.-Y., Yu W.-P., and Chen T.-Y. (2009) Blocking pore-open mutants of CLC-0 by amphiphilic blockers. J. Gen. Physiol. 133: 43-58.

    Zhang X.-D., and Chen T.-Y. (2009) Amphiphilic blockers punch through a mutant CLC-0 pore. J. Gen. Physiol. 133: 59-68.

    Chen T.-Y., and Hwang, T.-C. (2008) CLC-0 and CFTR: Chloride channels evolved from transporters. Physiol. Rev. 88: 351-387.

    Tseng P.-Y., Bennetts B., and Chen T.-Y. (2007) Cytoplasmic ATP inhibition of CLC-1 is enhanced by low pH. J. Gen. Physiol. 130: 217-221.

    Bykova E. A., Zhang X.-D., Chen T.-Y., and Zheng J. (2006) Large movement in the C-terminus of CLC-0 chloride channel during slow gating. Nature Struct & Mol. Biol. 13: 1115-1119.

    Chen T.-Y. (2005) Structure and function of ClC channels. Ann. Rev. Physiol. 67: 809-839.