Yohei Yokobayashi

Position Title
Associate Professor

3315 GBSF

Grad Group Affiliations

  • Biomedical Engineering

Specialties / Focus

  • Genomics, Proteomics and Metabolomics


  • BIM 161A Biomolecular Engineering, Fall
  • BIM 161L Biomolecular Engineering Laboratory, Winter

Professional Societies

  • American Chemical Society


  • 2001 PhD Chemistry The Scripps Research Institute
  • 1996 MS Chemistry and Biotechnology The University of Tokyo
  • 1994 BS Synthetic Chemistry The University of Tokyo


Kumar D, Kim SH, Yokobayashi Y. Combinatorially Inducible RNA Interference Triggered by Chemically Modified Oligonucleotides. J Am Chem Soc 2011; 133: 2783-2788.

Muranaka N, Yokobayashi Y. A synthetic riboswitch with chemical band-pass response. Chem Commun 2010; 46: 6825-6827.

Muranaka N, Yokobayashi Y. Posttranscriptional Signal Integration of Engineered Riboswitches Yields Band-Pass Output. Angew Chem Int Ed 2010; 49: 4653-4655.

Tuleuova N, An CI, Ramanculov E, Revzin A, Yokobayashi Y. Modulating endogenous gene expression of mammalian cells via RNA-small molecule interaction. Biochem Biophys Res Commun 2008; 376: 169-173.

Kumar D, An CI, Yokobayashi Y. Conditional RNA Interference Mediated by Allosteric Ribozyme. J Am Chem Soc 2009; 131: 13906-13907.

Muranaka N, Abe K, Yokobayashi Y. Mechanism-Guided Library Design and Dual Genetic Selection of Synthetic OFF Riboswitches. ChemBioChem 2009; 10: 2375-2381.

Muranaka N, Sharma V, Nomura Y, Yokobayashi Y. An efficient platform for genetic selection and screening of gene switches in Escherichia coli. Nucleic Acids Res 2009; 37: e39.

Sharma V, Nomura Y, Yokobayashi Y. Engineering complex riboswitch regulation by dual genetic selection. J Am Chem Soc 2008; 130: 16310-16315.

Nomura Y, Yokobayashi Y. Reengineering a natural riboswitch by dual genetic selection. J Am Chem Soc 2007; 129: 13814-13815.

Yoshida W, Yokobayashi Y. Photonic boolean logic gates based on DNA aptamers. Chem Commun 2007; 195-197.

An CI, Trinh VB, Yokobayashi Y. Artificial control of gene expression in mammalian cells by modulating RNA interference through aptamer-small molecule interaction. RNA 2006; 12: 710-716.

Y. Yokobayashi, R. Weiss, F. H. Arnold, 2002, "Directed evolution of a genetic circuit," Proceedings of the National Academy of Science, USA, 99: 16587-16591.