Department of Dermatology, School of Medicine
Using herpesvirus reactivation as a model to study gene regulation
Epigenetic gene regulation by using herpesvirus reactivation as a model system. Epigenetic components of chromatin, including host and viral factors that interact to facilitate both the establishment and maintainance of the chromatin state as well as the molecular transitions that take place during reactivation (“chromatin remodeling”). Post-translational modifications that are imparted on critical viral and host factors are also an area of research in our lab.
Cancer biology and posttranslational protein modification
Protein methylases and demethylases that regulate breast cancer cell growth
Grad Group Affiliations
- Biochemistry, Molecular, Cellular and Developmental Biology
Specialties / Focus
- Molecular Medicine
Honors and Awards
- Research Fellowships for Young Scientists of the Japan Society for Promotion of Science, 1998
- Uehara Memorial Postdoctoral Fellowship, 2002
- Universitywide AIDS Research Program Postdoctoral Fellowship Awards, 2003
- Plenary Honors Japanese Veterinary Medical Science, 2003
- Award for Excellence in Postdoctral Research at UC Davis, 2005
- California HIV/AIDS Research IDEA Award, 2007
- American Cancer Society Research Scolar Award 2013
- American Society for Microbiology
- The Japanese Society of Veterinary Science
- The Japanese Society for Virology
- 1997 BS/DVM Veterinary Medicine Kitasato University
- 2001 PhD Virology/Molecular Virology University of Tokyo
Campbell M, Watanabe T, Nakano K, Davis RR, Lyu Y, Tepper CG, Durbin-Johnson B, Fujimuro M, Izumiya Y. (2018) KSHV episomes reveal dynamic chromatin loop formation with domain specific gene regulation. Nat. Commun, 9: 49.
Zhou F, Shimoda M, Olney L, Lyu Y, Tran K, Jiang G, Nakano K, Davis RR, Tepper CG, Maverakis M, Campbell M, Li YP, Dandekar S, Izumiya Y. (2017) Oncolytic Reactivation of KSHV as a Therapeutic Approach for Primary Effusion Lymphoma. Mol. Cancer Ther, doi:10.1158/1535-7163. MCT-17-0041
Lyu Y, Nakano K, Davis RR, Tepper CG, Campbell M, Izumiya Y. (2017) ZIC2 is essential for maintenance of latency and is a target of an immediate-early protein during KSHV lytic reactivation. J. Virol, 91 (21); e00980-17 (selected as a JVI Spotlight Feature)
Chen CP, Lyu Y, Chuang F, Nakano K, Izumiya C, Jin D, Campbell M, Izumiya Y. (2017) Kaposi's sarcoma-associated herpesvirus hijacks RNA polymerase II to create a viral transcriptional factory. J Virol, 91 (11): e02491-16.
Wang LY, Hung CL, Chen YR, Yang JC, Wang J, Campbell M, Izumiya Y, Chen HW, Wang WC, Ann DK, Kung HJ. (2016) KDM4A coactivates E2F1 to regulate PDK-dependent metabolic switch between mitochondrial oxidation and glycolysis. Cell Rep, 16 (11): 3016-3027.
Bhatt AP, Wong JP, Weinberg MS, Host KM, Giffin LC, Buijnink J, van Dijk E, Izumiya Y, Kung HJ, Temple BR, Damania B. (2016) A viral kinase mimics S6 kinase to enhance cell proliferation. Proc Natl Acad Sci U S A, 113 (28): 7876-7881.
Kim KY, Wang DH, Campbell M, Huerta SB, Shevchenko B, Izumiya C, Izumiya Y. (2015) PRMT4-mediated Arginine methylation negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation. Mol Cell Biol, 35(1): 238-48.
Nakajima K, Zhu K, Sun YH, Hegyi B, Zeng Q, Murphy CJ, Small JV, Chen-Izu Y, Izumiya Y, Penninger JM, Zhao M. (2015) KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nat Commun, 6: 8532. doi: 10.1038/ncomms9532
Campbell M, Kung HJ, Izumiya Y. (2014) Long non-coding RNA and epigenetic gene regulation of KSHV. Viruses, 6(11): 4165-4177.
Campbell M, Kim KY, Chang PC, Huerta S, Shevchenko B, Wang DH, Izumiya C, Kung HJ, Izumiya Y. (2014) A lytic viral long noncoding RNA modulates the function of a latent protein. J Virol, 88(3): 1843-1848.
Kim KY, Huerta SB, Izumiya C, Wang DH, Martinez A, Shevchenko, B, Kung HJ, Campbell M, Izumiya, Y. (2013) Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated nuclear antigen regulates KSHV epigenome by association with histone demethylase, KDM3A. J Virol 87(12): 6782-6793.
Hsia DA, Tepper CG, Pochampalli MR, Hsia EY, Izumiya C, Huerta SB, Wright ME, Chen HW, Kung HJ, Izumiya Y. (2010) KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. Proc Natl Acad Sci U S A, 107(21): 9671-9676.
Pei-Ching Chang, Yoshihiro Izumiya, Chun-Yi Wu, Latricia D. Fitzgerald, Mel Campbell, Thomas J. Ellison, Kit S. Lam, Paul A. Luciw, and Hsing-Jien Kung (2010) Kaposi's sarcoma associated herpesvirus (KSHV) encodes a SUMO E3 ligase which is SIM-dependent and SUMO-2/3-specific. Journal of Biological Chemistry 285: 5266-5273
Paulette F. Suchodolski#, Yoshihiro Izumiya#, Blanca Lupiani, Dharani K. Ajithdoss, Lucy F. Lee, Hsing-Jien Kung and Sanjay M. Reddy (2010) Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens. Virology 399: 312-321
Izumiya Y, Izumiya C, Hsia D, Ellison TJ, Luciw PA, Kung HJ. (2009) NF-κB serves as a cellular sensor of KSHV latency and negatively regulates K-Rta by antagonizing the RBP-Jκ coactivator. J Virol, 83(9): 4435-4446.
Thomas J. Ellison#, Yoshihiro Izumiya#*, Chie Izumiya, Paul A. Luciw, and Hsing-Jien Kung (2009) A Comprehensive Analysis of Recruitment and Transactivation Potential of K-Rta and K-bZIP during Reactivation of Kaposi’s Sarcoma-Associated Herpesvirus. Virology 387: 76-88
Paulette F. Suchodolski#, Yoshihiro Izumiya#, Blanca Lupiani, Dharani K. Ajithdoss, Oren Gilad, Lucy F. Lee, Hsing-Jien Kung, and Sanjay M. Reddy (2009) Homodimerization of Marek's Disease Virus-Encoded Meq Protein Is Not Sufficient for Transformation of Lymphocytes in Chickens. Journal of Virology 83: 859-869
Pei-Ching Chang, Latricia D. Fitzgerald, Albert Van Geelen, Yoshihiro Izumiya, Thomas J. Ellison, Don-Hong Wang, David K. Ann, Paul A. Luciw and Hsing-Jien Kung (2009) Kruppel-Associated Box Domain-Associated Protein-1 as a Latency Regulator for Kaposi's Sarcoma-Associated Herpesvirus and Its Modulation by the Viral Protein Kinase. Cancer Research 69: 5681-5689
Oliver Gautschi, Clifford G. Tepper, Phillip R. Purnell, Yoshihiro Izumiya, Christopher P. Evans, Tim P. Green, Pierre Y. Desprez, Primo N. Lara, David R. Gandara, Philip C. Mack, and Hsing-Jien Kung (2008) Regulation of Id1 Expression by Src: Implications for Targeting of the Bone Morphogenetic Protein Pathway in Cancer. Cancer Research 68: 2250-2258
Yoshihiro Izumiya, Chie Izumiya, Albert M. VanGeelen, Don-Hong Wang, Kit S. Lam, Paul A. Luciw, Hsing-Jien Kung (2007) Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP. Journal of Virology 81: 1072-1082
Alon M. Levy, Oren Gilad, Liang Xia, Yoshihiro Izumiya, Jonathan Choi, Tsalenko A, Yakhini Z, Richard L. Witter, Lucy F. Lee, Carol J. Cardona, Hsing-Jien Kung. (2005) Meq transforms chicken cells via the v-Jun transcriptional cascade: a converging transforming pathway for Avian oncoviruses. Proceedings National Academy of Science 102:14831-14836
Yoshihiro Izumiya, Thomas J. Ellison, Edward T.H. Yeh, Jae U. Jung, Paul A. Luciw, Hsing-Jien Kung. (2005) Kaposi’s sarcoma-associated Herpesvirus K-bZIP represses gene transcription via SUMO modification. Journal of Virology 79:9912-9925