Yoshikazu Takada

Yoshikazu Takada

Position Title

Department of Dermatology, School of Medicine

3300 Research III Bldg/UCDMC, Sacramento, CA 95817

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • ImmunologyPharmacology and Toxicology

Professional Societies

  • American Association for Canver research, Society of Investigative Dermatology


  • 1976 MD General Medicine Wakayama Medical School, Wakayama, Japan
  • 1981 PhD Biochemistry Kyushu Dental School, Kitakyushu, Japan


(Selected from over 120 publications)

Y. Takada, J.L. Strominger, and M.E. Hemler, 1987, The VLA family of heterodimers are members of a superfamily of molecules involved in adhesion and embryogenesis. Proc. Natl. Acad. Sci. U.S.A. 84, 3239-3243.

Y. Takada, C. Huang, and M.E. Hemler, 1987, Fibronectin receptor structures within the VLA family of heterodimers. Nature 326, 607-609.

Y. Takada, M.J. Elices, C. Crous, and M.E. Hemler, 1989, The primary structure of the alpha4 subunit of VLA-4: Homology to other integrins and a possible cell-cell adhesion function. EMBO J. 8, 1361-1368.

Y. Takada and M.E. Hemler, 1989, The primary structure of the VLA-2/collagen receptor alpha2 subunit (platelet GP Ia): Homology to other integrins and the presence of possible collagen binding domain. J. Cell Biol. 109, 397-407.

Y. Takada, E. Murphy, P. Pil, C. Chen, M.H. Ginsberg, and M.E. Hemler, 1991, Molecular cloning and expression of the cDNA for alpha3 subunit of the human alpha3beta1 (VLA3), an integrin receptor for Fibronectin, laminin and collagen. J. Cell Biol. 115, 257-266.

Y. Takada, J. Ylanne, D. Mandelman, W. Puzon, and M. Ginsberg, 1992, A point mutation of integrin beta1 subunit blocks binding of a5beta1 with fibronectin and invasin but not recruitment to adhesion plaques. J. Cell Biol. 119, 913-921.

Y. Takada and W. Puzon, 1993, Identification of a regulatory region of integrin beta1 subunit using activating and inhibiting antibodies. J. Biol. Chem. 268, 17596-17601.

T. Kamata, W. Puzon, and Y. Takada, 1994, Identification of putative ligand binding sites within I domain of integrin alpha2beta1 (VLA-2, CD49b/CD29). J. Biol. Chem. 269, 9659-9663.

A. Irie, T. Kamata, W. Puzon-McLaughlin, and Y. Takada, 1995, Critical amino acid residues for ligand binding are clustered in a predicted b-turn of the third N-terminal repeat in the integrin a4 and a5 subunits, Embo J. 14, 5550-5556.

A. Irie, T. Kamata, and Y. Takada, 1997, Multiple loop structures critical for ligand binding of the integrin ?4 subunit in the upper face of the b-propeller model. Proc. Natl. Acad. Sci. 94, 7198-7203.

X.-P. Zhang, T. Kamata, K. Yokoyama, W. Puzon-McLaughlin, and Y. Takada,1998, Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin avb3. J. Biol. Chem. 273, 7345-7350.

T. Kamata, R.C. Liddington, and Y. Takada, 1999, Interaction between collagen and the alpha2 I-domain of integrin alpha2beta1: Critical role of conserved residues in the MIDAS region. J. Biol. Chem. 274, 32108-32111.

K. Yokoyama, H.P. Erickson, Y. Ikeda, and Y. Takada, 2000, Identification of amino acid sequences in fibrinogen g-chain and tenascin C C-terminal domains critical for binding to integrin avb3. J Biol. Chem. 275, 16891-16898.

K. Eto, W. Puzon-McLaughlin, D. Sheppard, A. Sehara-Fujisawa, X.-P. Zhang, and Y. Takada, 2000, RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction. J. Biol. Chem. 275, 34922-34930.

G. Weitz-Schmidt, K. Welzenbach, V. Brinkmann, T. Kamata, J. Kallen, C. Bruns, S. Cottens, Y. Takada, and U. Hommel, 2001, Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nature Med. 7, 687-692.

T. Tarui, A.P. Mazar, D.B. Cines, and Y. Takada, 2001, Urokinase-type plasminogen activator (CD87) is a ligand for integrins and mediates cell-cell interaction. J. Biol. Chem. 276, 3983-3990.

T. Tarui, L.A. Miles, and Y. Takada, 2001, Specific interaction of angiostatin with integrin alphavbeta3 in endothelial cells. J. Biol. Chem. 276, 39562-39568.

T. Kamata, K. Tieu, A. Irie, T. Springer, and Y. Takada, 2001, Amino Acid Residues in the aIIb subunit that are critical for ligand binding to integrin alphaIIbbeta3 are clustered in the B-propeller model. J. Biol. Chem. 276, 44275-44283.

T. Nakamura, P.R. Lozano, Y. Ikeda, Y. Iwanaga, A. Hinek, S. Minamisawa, C.-F. Cheng, K. Kobuke, Y. Takada, K. Tashiro, J.J. Ross, T. Honjo, and K.R. Chien, 2002, DANCE/fibulin-5, a novel integrin ligand, is essential for elastogenesis and related skin and cardiopulmonary diseases. Nature, 415, 171-175. \

T. Kamata, K.K. Tieu, T. Tarui, Wilma Puzon-McLaughlin, N. Hogg, and Y. Takada, 2002, The role of the CPNKEKEC sequence in the alpha3 subunit I-like domain in regulation of integrin alphaLbeta2 (LFA-1). J Immunol, 168, 2296-2301.

T. Tarui, M. Majumdar, L.A. Miles, W. Ruf, and Y. Takada, 2002, Plasmin-induced migration of endothelial cells: a potential target for the anti-angiogenic action of angiostatin. J. Biol. Chem. 277, 33564-33570

K. Eto, C. Huet, T. Tarui, S. Kupriyanov, HZ. Liu, W. Puzon-McLaughlin, XP. Zhang, D. Sheppard, E. Engvall, and Y. Takada. 2002, Functional classification of ADAMs based on a conserved motif for binding to integrin alpha9beta1; implications for sperm-egg binding and other cell interactions. J Biol Chem. 277,17804-17810

G.B.Legge, G.M. Morris, M.F. Sanner, Y. Takada, A.J. Olson, and F. Grynszpan, 2002, Model of the alphaLbeta2 integrin I-domain/ICAM-1 DI interface suggests that subtle changes in loop orientation determine ligand specificity. Proteins, 48, 151-160.

T. Tarui, N. Andronicos, RP. Czerkay, AP. Mazar, K. Bdeir, GC. Parry, A. Kuo, DJ. Loskutoff, DB. Cines, and Y. Takada. 2003, Critical role of integrin alpha 5beta 1 in urokinase (uPA) /urokinase receptor (uPAR, CD87) signaling. J Biol Chem, 278, 29863-29872

M. Schwarz, Rottgen P, Takada Y, Le Gall F, Knackmuss S, Bassler N, Buttner C, Little M, Bode C, Peter K. 2004, Single-chain antibodies for the conformation-specific blockade of activated platelet integrin alphaIIbbeta3 designed by subtractive selection from naive human phage libraries. FASEB J. 18(14):1704-6.

H. Muramatsu, Zou P, Suzuki H, Oda Y, Chen GY, Sakaguchi N, Sakuma S, Maeda N, Noda M, Takada Y, Muramatsu T. 2004, alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor. J Cell Sci. 117(Pt 22):5405-15.

A. Dorfleutner, E, Hintermann, T. Tarui, Y Takada, W. Ruf. 2004, Cross-talk of integrin alpha3beta1 and tissue factor in cell migration. Mol Biol Cell. 15(10):4416-25.

M. Majumdar, Tarui T, Shi B, Akakura N, Ruf W, Takada Y. 2004, Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha9beta1. J Biol Chem. 279(36):37528-34.

KL Graham, FE Fleming, P Halasz, MJ Hewish, HS Nagesha, IH Holmes, Y Takada, BS Coulson. 2005. Rotaviruses interact with alpha4beta7 and alpha4beta1 integrins by binding the same integrin domains as natural ligands. J Gen Virol. 86(Pt 12):3397-408.

T Tarui, N Akakura, M Majumdar, N Andronicos, J Takagi, AP Mazar, K Bdeir, A Kuo, SV Yarovoi, DB Cines, Y Takada. 2006. Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation. Thromb Haemost. 95(3):524-34.

PL Wu, SC Lee, CC Chuang, S Mori, N Akakura, WG Wu, Y Takada. 2006. Non-cytotoxic cobra cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption. Identification of cardiotoxins as non-RGD integrin-binding proteins of the Ly-6 family. J Biol Chem. 281(12):7937-45.

L. Peng, R. Liu, J. Marik, X. Wang, Y. Takada, KS. Lam, 2006, Identification of High-Affinity Cancer Targeting Agents against alpha4beta1 Integrin Using the Combinatorial Chemistry Approach, Nature Chemical Biology, 2(7):381-9

N. Akakura, C. Hoogland, Y K. Takada, J Saegusa, XJ. Ye, F.-T. Liu, A. T.-W. Cheung, and Y. Takada, 2006, The C-terminal globular domain of fibrinogen ? chain suppresses angiogenesis and tumor growth. Cancer Research. 66, 9691-9697

FE Fleming, KL Graham, K Taniguchi, Y Takada, BS Coulson, 2007, Rotavirus-neutralizing antibodies inhibit virus binding to integrins ?2?1 and ?4?1, Archives of Virology, 152(6): 1087-1101.

Takada Y, Ye X, Simon S (2007) The integrins. Genome biology 8(5): 215.

Versteeg HH, Schaffner F, Kerver M, Petersen HH, Ahamed J, B. Felding-Habermann, Y. Takada, B.M. Mueller, and W. Ruf. (2008) Inhibition of tissue factor signaling suppresses tumor growth. Blood 111(1): 190-199.