Yu-Fung Lin

Yu-Fung Lin

Position Title
Associate Professor

Unit
Department of Anesthesiology and Pain Medicine, School of Medicine
Department of Physiology and Membrane Biology, School of Medicine

TUPPER HALL, Rm. 4144
Bio

Profile Introduction

Cellular and molecular physiology of ion channels: structure-function relationship and modulation

Research Interests

Functional modulation of potassium channels

Cellular and molecular physiology of ion channels: structure-function relationship and modulation

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Molecular, Cellular and Integrative Physiology

Specialties / Focus

  • Cellular Physiology
  • Molecular Physiology
  • Neurophysiology

Courses

  • MCP 210A Molecular and Cellular Physiology, Fall
  • HPH 400 Medical Physiology, Fall
  • PTX 202 Principles of Pharmacology and Toxicology: Cellular and Molecullar Basis of Drug Action, Winter
  • HPH 115 Physiology of Cannabis, Spring
  • HPH 440 Cannabis and Cannabinoids in Physiology and Medicine, Winter
  • HPH 493C Care of Critically Ill Surgical Patient: Use of Physiological Principles (Special Study Module for MS4 students), Spring

Labs

  • 4210/4212 Tupper Hall
    • Dai-Min Zhang (postdoctoral fellow)

Honors and Awards

  • Duncan McCarthy Award, Michigan Chapter Society for Neuroscience, 1994
  • Lothman Fellowship, The Epilepsy Foundation of America, 1996-1997
  • Health System Research Award, UC Davis 2005-2007
  • Harrison Endowed Chair in Diabetes Research Award, UC Davis 2006
  • American Heart Association Scientist Development Grant (National Center) 2007-2011
  • Research Insurance Grant, UC Davis 2007-2008
  • Genome Center Proteomics Core Facility Pilot Project, UC Davis 2009

    Professional Societies

    • Society for Neuroscience
    • American Physiological Society
    • American Association for the Advancement of Science
    • Biophysical Society
    • American Heart Association

    Degrees

    • 1995 PhD Physiology University of Michigan, Ann Arbor, Michigan
    • 1986 MS Zoology National Taiwan University, Taipei, Taiwan
    • 1984 BS Zoology National Taiwan University, Taipei, Taiwan

    Publications

    1987 Lin, A.M.Y., Pan, C.M., Lin, Y.F., Kuo, J.S. and Chai, C.Y. A cardioinhibitory area in the midbrain central tegmental field of cats. Brain Res. Bull. 18: 699-707.

    1988 Chai, C.Y., Lin, Y.F., Lin, A.M.Y., Pan, C.M., Lee, E.H. and Kuo, J.S. Existence of a powerful inhibitory mechanism in the medial region of caudal medulla--with special reference to the paramedian reticular nucleus. Brain Res. Bull. 20: 51-28.

    1990 Chai, C.Y., Lin, Y.F., Wang, H.Y., Wu, W.C., Yen, C.T., Kuo, J.S. and Wayner, M.J. Inhibition of spinal reflexes by paramedian reticular nucleus. Brain Res. Bull. 25: 581-588.

    1991 Yen, C.T., Hwang, J.C., Su, C.K., Lin, Y.F., Yang, J.M. and Chai, C.Y. Differential actions of the median region of caudal medulla on autonomic nerve activities. Clin. Exp. Pharmacol. Physiol. 18: 743-751.

    1992 Chai, C.Y., Wu, W.C., Wang, S., Su, C.K., Lin, Y.F., Yen, C.T., Kuo, J.S. and Wayner, M.J. Coexistence of autonomic and somatic mechanisms in the pressor areas of medulla in cats. Brain Res. Bull. 29: 15-26.

    1994 Lin, Y.F., Browning, M.D., Dudek, E.M. and Macdonald, R.L. Protein kinase C enhances bovine alpha1beta1gamma2L GABA(A) receptor whole-cell currents expressed in L929 fibroblasts. Neuron 13: 1421-1431.

    1996 Lin, Y.F., Angelotti, T.P., Dudek, E.M., Browning, M.D. and Macdonald, R.L. Protein kinase C phosphorylation of the beta1 and gamma2L subunits of the GABA(A) receptor enhances whole-cell currents expressed in L929 fibroblasts. Mol. Pharmacol. 50: 185-195.

    2000 Lin, Y.F., Jan, Y.N. and Jan, L.Y. Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cell. EMBO J. 19: 942-955.

    2000 Minor, D.L., Lin, Y.F., Mobley, B.C., Avelar, A., Jan, Y.N., Jan, L.Y. and Berger, J.M. The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell 102: 657-670.

    2001 Ma, D., Zerangue, N., Lin. Y.F., Collins, A., Yu, M., Jan, Y.N. and Jan, L.Y. Role of ER export signals in controlling surface potassium channel numbers. Science 291: 316-319.

    2001 Yi, B.A., Lin, Y.F., Jan, Y.N. and Jan, L.Y. Yeast screen for constitutively active mutant G protein-activated potassium channels. Neuron 29: 657-667.

    2001 Yi, B.A., Minor, D.L., Lin, Y.F., Jan, Y.N. and Jan, L.Y. Controlling potassium channel activities: interplay between the membrane and intracellular factors. Proc. Natl. Acad. Sci. USA 98: 11016-11023.

    2004 Bichet, D., Lin, Y.F., Ibarra, C.A., Huang, C.S., Yi, B.A., Jan, Y.N. and Jan, L.Y. Evolving potassium channels via yeast selection reveals structural elements important for selectivity. Proc. Natl. Acad. Sci. USA 101: 4441-4446.

    2004 Lin, Y.F., Raab-Graham, K., Jan, Y.N. and Jan, L.Y. Nitric oxide stimulation of ATP-sensitive potassium channels: Involvement of Ras/MAPK kinase pathway and contribution to neuroprotection. Proc. Natl. Acad. Sci. USA 101: 7799-7804.

    2007 Mao, X., Chai, Y. and Lin, Y.F. Dual regulation of ATP-sensitive potassium channels by caffeine. Am. J. Physiol. Cell Physiol. 292: C2239-C2258.

    2007 Misaki, N., Mao, X., Lin, Y.F., Suga, S., Li, G.H., Liu, Q., Chang, Y., Wang, H, Wakui, M. and Wu, J. Iptakalim, a vascular KATP channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release. J. Pharmacol. Exp. Ther. 322: 871-878.

    2008 Lin, Y.F. and Chai, Y. Modulation of the ATP-sensitive potassium channel by extracellular signal-regulated kinase-mediated phosphorylation. Neuroscience 152: 371-380.

    2008 Chai, Y. and Lin, Y.F. Dual regulation of the ATP-sensitive potassium channel by activation of cyclic GMP-dependent protein kinase. Pflügers Archiv-European J. Physiol. 456: 897-915.

    2009 Chen, T.Y., Lin, Y.F. and Zheng, J. Electrophysiological measurements of membrane proteins, T. Jue, (ed), Fundamental Concepts in Biophysics, Vol. 1, Series: Handbook on Biophysics, Humana Press, Totowa, NJ.

    2010 Chai, Y. and Lin, Y.F. Stimulation of neuronal K(ATP) channels by cGMP-dependent protein kinase: Involvement of ROS and 5-hydroxydecanoate-sensitive factors in signal transduction. Am. J. Physiol. Cell Physiol. 298(4): C875-C892.

    2011 Chai, Y., Zhang, D.M. and Lin, Y.F. Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade. PLoS ONE 6(3): e18191. doi:10.1371/journal.pone.0018191

    2014 Zhang, D.M, Chai, Y., Erickson, J., Brown, J.H., Bers, D.M. and Lin, Y.F. Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes. J. Physiol. (London). 592: 971-990.

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