For the first time scientists have been able to watch individual steps in the replication of a single DNA molecule, with some surprising findings. For one thing, there’s a lot more randomness at work than has been thought.
“It’s a different way of thinking about replication that raises new questions,” said Stephen Kowalczykowski, distinguished professor in microbiology and molecular genetics at the University of California, Davis, and at the UC Davis Comprehensive Cancer Center. The work is published June 15 in the journal Cell with co-authors James Graham, postdoctoral researcher at UC Davis, and Kenneth Marians, Sloan Kettering Cancer Center.
Genetics and Microbiology