proteins

New Cryo-Electron Microscope Powers Biological Sciences Discovery

Chancellor Gary S. May and Mark Winey, dean of the College of Biological Sciences, recently cut the ribbon on a new cryo-EM facility in Briggs Hall. The $2.5 million microscope is open to all campus researchers. It can collect thousands of images a day to assemble into movies showing how proteins and other biomolecules do their work.

Mitochondrial Chitter-Chatter: Unveiling the Molecular Structures of Cellular Respiration

In order to generate energy, our bodies transfer electrons from food—sugars, fats and proteins—to molecular oxygen, which allows our cells to respire and function. Performed by the mitochondrial electron transport chain (ETC), this process creates ATP, the “molecular currency” for energy in the cell. In a Molecular Cell study, Assistant Professor James Letts, Department of Molecular and Cellular Biology, and colleagues reveal further nuances of the ETC.

Visualizing “Unfurling” Microtubule Growth

Microtubule fibers are hollow rods made of much smaller tubulin subunits that spontaneously assemble at one end of the rod, but exactly how they do this inside the crowded environment of living cells has been a mystery. UC Davis researchers have uncovered the mechanism that puts these blocks in place, illustrated in a new animation.