Aldrin V. Gomes

Aldrin Gomes

Position Title

Department of Neurobiology, Physiology and Behavior, College of Biological Sciences
Department of Physiology and Membrane Biology, School of Medicine

187 Briggs Hall

Profile Introduction

We are interested in the molecular mechanisms of signal transduction, particularly in the role of protein homeostasis (proteostasis) in cardiovascular diseases.

Research Interests

Muscle Physiology and Proteomics Laboratory

Impaired protein degradation is associated with many cardiac and skeletal muscle diseases. Our laboratory is interested in investigating the signaling pathways involved in proteostasis (protein homeostasis) in cardiac and skeletal muscle diseases. Our laboratory is also interested in the side effects of commonly used drugs, such as ibuprofen, on the heart and other tissues.

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Molecular, Cellular and Integrative Physiology

Specialties / Focus

  • Biochemistry
  • Cell Biology
  • Cellular Physiology
  • Differentiation, Morphogenesis and Wound Healing
  • Exercise Physiology
  • Metabolic Physiology
  • Molecular Physiology
  • Molecular Physiology
  • Signal Transduction


  • EXB 110 Exercise Metabolism, Spring
  • NPB 110A From Molecules to Individuals, Fall
  • NPB 101 Systemic Physiology, Winter


  • Muscle Physiology and Proteomics Laboratory/176 Briggs Hall
    • Shuchita Tiwari, PhD; Rong Pei, MD; Rasheed Sule, BS; Rômulo Leão Silva Neris, BS;

Honors and Awards

  • Alpha Omega Merit Award from the University of the West Indies School of Medicine, 1995
  • Young Scientist Award from the International Union of Biochemistry and Molecular Biology, 1997
  • American Society Biochemistry and Molecular Biology Travel Fellowship, 2000
  • Biochemical Society Fellowship, 2000
  • Scientist Development Grant from the Muscular Dystrophy Association, 2002
  • American Heart Association Travel Award, 2004
  • Scientist Developmental Grant from the American Heart Association, 2008
  • Hellman Fellow, 2010
  • Fellow of the American Physiological Society (Cardiovascular Section) 2015
  • UC Davis Chancellor's Fellow 2016-2017
  • Fellow of the American Heart Association (FAHA) 2017
  • Chancellor's Award for Excellence in Mentoring Undergraduate Research 2019

    Professional Societies

    • American Heart Association (AHA)
    • American Physiological Society
    • Biophysical Society
    • Cardiac Society
    • International Society for Heart Research


    • 1998 PhD (Biochemistry) University of the West Indies, St. Augustine, Trinidad and Tobago


    Tiwari, S., Mishra, M., Newens, J., Gomes, A.V. (2020) Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen. Scientific Reports. Feb 25;10(1):3386. See Eurekalert about article.

    Mishra M, Tiwari S, Gunaseelan A, Li D, Hammock BD, Gomes AV. (2019) Improving the sensitivity of traditional Western blotting via Streptavidin containing Poly-horseradish peroxidase (PolyHRP). Electrophoresis.,40(12-13): 1731-1739.

    Sander H, Wallace S, Plouse R, Tiwari S, Gomes AV. (2019) Ponceau S waste: Ponceau S staining for total protein normalization. Analytical Biochemistry, 575: 44-53.

    Kazmierczak K, Liang J, Yuan CC, Yadav S, Sitbon YH, Walz K, Ma W, Irving TC, Cheah JX, Gomes AV, Szczesna-Cordary D. (2019) Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain. FASEB Journal, 33(3): 3152-3166.

    Hwang HV, Lin Y, Rebuffatti MN, Tran DT, Lee L, Gomes AV, Li CS, Knowlton AA. (2019) Impaired proteostasis in senescent vascular endothelial cells: a perspective on estrogen and oxidative stress in the aging vasculature. American Journal of Physiology: Heart and Circulatory Physiology, 316(2): H421-H429. See podcast of article.

    Yuan CC, Kazmierczak K, Liang J, Zhou Z, Yadav S, Gomes AV, Irving TC, Szczesna-Cordary D. (2018) Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice. Proc Natl Acad Sci U S A. 15(10):E2338-E2347.

    Gomes AV. (2018) Spatiotemporal Multi-Omics-Derived Atlas of Calcific Aortic Valve Disease. Circulation. Jul 24;138(4):394-396

    Gilda JE, Gomes AV. (2017) Proteasome dysfunction in cardiomyopathies. The Journal of physiology 595(12):4051-4071.

    Yuan CC, Kazmierczak K, Liang J, Kanashiro-Takeuchi R, Irving TC, Gomes AV, Wang Y, Burghardt TP, Szczesna-Cordary D. (2017) Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice. Cardiovascular research 113(10):1124-1136.

    Mishra M, Tiwari S, Gomes AV. (2017) Protein purification and analysis: next generation Western blotting techniques. Expert Rev Proteomics. 14:1037-1053.

    Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. (2017) Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behavioural brain research 326:69-76.

    Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD. (2017) Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins & other lipid mediators. 133:68-78.

    Gilda JE, Lai X, Witzmann FA, Gomes AV. (2016) Delineation of molecular pathways involved in cardiomyopathies caused by troponin T mutations. Molecular and Cellular Proteomics. 15(6):1962-81. 

    Ghosh R, Hwang SM, Cui Z, Gilda JE, Gomes AV. (2016) Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells. Journal of Molecular and Cellular Cardiology. 94:131-144.

    Carbonell T, Alva N, Sanchez-Nuño S, Dewey S, Gomes AV. (2016) Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System. Oxidative medicine and cellular longevity 2016:9324692.

    Ghosh R, Goswami SK, Feitoza LF, Hammock B, Gomes AV. (2016) Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. Int J Cardiol. 223:923-935.

    Nguyen S, Siu R, Dewey S, Cui Z, Gomes AV. (2016) Amino Acid Changes at Arginine 204 of Troponin I Result in Increased Calcium Sensitivity of Force Development. Frontiers in physiology 7:520.

    Landry M, Gomes AV. (2016) Antibodies: Half of samples fail protein-blot tests. Nature. 529(7584):25

    Gilda JE, Xu Q, Martinez ME, Nguyen ST, Chase PB, Gomes AV. (2016) The functional significance of the last 5 residues of the C-terminus of cardiac troponin I. Arch Biochem Biophys. 601:88-96. 

    West DW, Baehr LM, Marcotte GR, Chason CM, Tolento L, Gomes AV, Bodine SC, Baar K. (2016) Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle. J Physiol. 15;594(2):453-68.

    Klionsky DJ et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12(1):1-222.

    Lindsey ML, Mayr M, Gomes AV, Delles C, Arrell DK, Murphy AM, Lange RA, Costello CE, Jin YF, Laskowitz DT, Sam F, Terzic A, Van Eyk J, Srinivas PR; (2015) Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. AHA Council on Functional Genomics and Translational Biology, Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council on Hypertension, and Stroke Council. Circulation. 132(9):852-72.

    Gomes AV, Kazmierczak K, Cheah JX, Gilda JE, Yuan CC, Zhou Z, Szczesna-Cordary D. (2015) Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains. J Muscle Res Cell Motil. 36(6):447-61.

    Gilda JE, Ghosh R, Cheah JX, West TM, Bodine SC, Gomes AV. (2015) Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS). PLoS One. 2015 10(8):e0135392. 

    Carbonell T, Gomes AV. (2015) Dynamic regulation of the proteasome by systolic overload. Journal of Molecular and Cellular Cardiology 87:1-3.

    Negroni JA, Morotti S, Lascano EC, Gomes AV, Grandi E, Puglisi JL, Bers DM. (2015) β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. Journal of Molecular and Cellular Cardiology 81:162-75.

    Gomes AV, Rajasekaran NS, Pi X. (2015) Redox Signaling and the Cardiovascular and Skeletal Muscle System. Oxid Med Cell Longev. 2015:849095.

    Ghosh R, Alajbegovic A, Gomes AV. (2015) NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species. Oxidative Medicine and Cellular Longevity. 2015:536962. 

    Gilda JE, Gomes AV. (2015) Western blotting using in-gel protein labeling as a normalization control: stain-free technology. Methods Mol Biol. 1295: 381 -91.

    Jamart C, Gomes AV, Dewey S, Deldicque L, Raymackers JM, Francaux M. (2014) Regulation of ubiquitin-proteasome and autophagy pathways after acute LPS and epoxomicin administration in mice. BMC Musculoskelet Disord.15:166.

    Ghosh R, Gilda JE, Gomes AV. (2014) The necessity of and strategies for improving confidence in the accuracy of western blots. Expert Rev Proteomics. 11(5):549-60.

    Cui, Z., Scruggs, S.B., Gilda, J.E., Ping, P., Gomes, A.V. (2014) Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond. J Mol Cell Cardiol. 71:32-42.

    Cui, Z., Hwang, S.M., and Gomes A.V. (2014) Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Mol Cell Biol. 34(1):96-109.

    Narashimhan M., Hong J., Atieno N., Muthusamy V.R., Davidson C.J., Abu-Rmaileh N., Richardson R., Gomes A.V., Hoidal J.R., Rajasekaran N.S. (2014) Nrf2 Deficiency Promotes Apoptosis and Impairs Pax7/MyoD Expression in Aging Skeletal Muscle Cells. Free Radical Biology and Medicine. 71:402-14.

    Wecksler A.T., Hwang S.H., Wettersten H.I., Gilda J.E., Patton A., Leon L.J., Carraway K.L. 3rd, Gomes A.V, Baar K., Weiss R.H., Hammock B.D. (2014) Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs. 25(4):433-46.

    Puglisi JL, Goldspink PH, Gomes AV, Utter MS, Bers DM, Solaro RJ. (2014) Influence of a constitutive increase in myofilament calcium-sensitivity on calcium-fluxes and contraction of mouse heart ventricular myocytes. Arch Biochem Biophys. 15;552-553

    Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes AV, Shelton GD, Lieber RL, Chen J. (2014) Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Human Molecular Genetics. 23(1):209-225.

    Cui Z, Gilda JE, Gomes AV. (2014) Crude and purified proteasome activity assays are affected by type of microplate. Anal Biochem. 446: 44–52.

    Dewey, S., Lai, X., Witzmann,F., Sohal, M., Gomes, A.V. (2013) Proteomic Analysis of Hearts from Akita Mice Suggests Increases in Soluble Epoxide Hydrolase and Antioxidative Programming are Key Changes in Early Stages of Diabetic Cardiomyopathy. Journal of Proteome Research, 12(9): 3920–3933.

    Gomes A.V. (2013) Genetics of Proteasome Diseases. Scientifica. 2013:637629.

    Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. (2013) Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovascular Research, 100(1):63-73

    Gilda, J.E., Gomes, A.V. (2013) How phosphorylated can it get? Cardiac myosin binding protein C phosphorylation in heart failure. Journal of Molecular Cellular Cardiology, 62(108): 108-110.

    Gilda, J.E., Gomes, A.V. (2013) Stain free total protein staining is a superior loading control to β-actin for Western blots. Analytical Biochemistry,440(2): 186-188.

    Rajagopalan, V.,Zhao, M.,Reddy, S., Fajardo, G.,Wang, X., Dewey, S., Gomes, A,V., Bernstein, D. (2013) Altered Ubiquitin-Proteasome Signaling in Right Ventricular Hypertrophy and Failure. American Journal of Physiology, 305(4): H551-62.

    Xu, Q., Cui, Z., Venkatraman, G., Gomes, A.V. (2012) The use of biophysical proteomic techniques in advancing our understanding of diseases. Biophysical Reviews 4, 125-135.

    Gomes AV, Waddell DS, Siu R, Stein M, Dewey S, Furlow JD, Bodine SC. (2012) Upregulation of proteasome activity in muscle RING finger 1-null mice following denervation. FASEB J. 26:2986-99.

    Pinto, J.R., Gomes, A.V., Jones, M.A., Liang, J., Nguyen ,S., Miller, T., Parvatiyar, M.S,. Potter J.D. (2012) The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation. J Biol Chem. 287:37362-70.

    Iorga, A., Dewey, S., Partow-Navid1, R., Gomes AV, Mansoureh, E. (2012) Pregnancy Is Associated with Decreased Cardiac Proteasome Activity and Oxidative Stress in Mice. PLOS One. 7(11): e48601.

    Szczesna-Cordary D, Morimoto S, Gomes AV, Moore JR. (2012) Cardiomyopathies:classification, clinical characterization, and functional phenotypes.Biochemistry Research International, 870942.

    Cui, Z., Dewey, S., Gomes, A.V. (2011) Cardioproteomics: advancing the discovery of signaling mechanisms involved in cardiovascular diseases. Am. J. Cardiovasc. Dis. 1: 274-292.

    Hwee, D.T., Gomes, A.V., Bodine, S.C. (2011) Cardiac Proteasome Activity in Muscle Ring Finger-1 Null Mice at Rest and Following Synthetic Glucocorticoid Treatment. Am. J. Physiol. Endocrinol. Metab. 301:E967-77.

    Dewey, S., Xu, Q., Gomes, A. (2010) Static and dynamic properties of the HCM myocardium. J Mol Cell Cardiol. 49:715-8.

    Divald, A., Kivity, S., Wang, P., Hochhauser, E., Roberts, B., Teichberg, S., Gomes, A.V., Powell, S.R., (2010) Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits. Circulation Research. 106: 1829-38.

    Dewey, S., Gomes, A.V. (2010) Non-Antigen Processing Diabetic Cardiac Immunoproteasomes. J. Mol. Cell. Cardiol. 49: 1-4.

    Xu, Q., Dewey, S., Nguyen, S., Gomes, A.V. (2010) Malignant and benign mutations in familial cardiomyopathies: Insights into mutations linked to complex cardiovascular phenotypes. J. Mol. Cell. Cardiol. 48: 899-909.

    Tikunova, S.B., Liu, B., Swindle, N., Little, S.C., Gomes, A.V., Swartz, D.R., Davis, J.P. (2010) Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems. Biochemistry. 49:1975-84.

    Willott, R.H., Gomes, A.V., Chang, A.N., Parvatiyar, M.S., Pinto, J.R., Potter, J.D. (2010) Mutations in Troponin that cause HCM, DCM AND RCM: What can we learn about thin filament function? J. Mol. Cell. Cardiol. 48:882-92.

    Gomes, A.V., Young, G.W., Wang, Y., Zong, C., Eghbali, M., Drews, O., Lu, H., Stefani, E., Ping, P. (2009) Contrasting proteome biology and functional heterogeneity of the 20S proteasome complexes in mammalian tissues. Mol Cell Proteomics. 8:302-15.

    Mayr M., Grainger, D., Mayr, U., Leroyer, A.S., Leseche, G., Sidibe, A., Herbin, O., Yin, X., Gomes, A.V., Madhu, B., Griffiths, J.R., Xu, Q., Tedgui, A. and Boulanger, C.M. (2009) Proteomics, Metabolomics, and Immunomics on Microparticles Derived from Human Atherosclerotic Plaques. Circ. Cardiovasc. Genet. 46268-77.

    Mayr, M., Liem, D., Zhang, J., Li, X., Avliyakulov, N.K., Yang, J.I., Young, G., Vondriska, T.M., Ladroue, C., Madhu, B., Griffiths, J.R., Gomes, A., Xu, Q., Ping, P. (2009) Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J. Mol. Cell. Cardiol. 46:268-77.

    Drews, O., Wildgruber, R., Zong, C., Sukop, U., Nissum, M., Weber, G., Gomes, A.V., Ping, P. (2007) Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Mol. Cell. Proteomics 6:2021-2031.

    Gomes, A.V. Zong, C., Edmondson, R., Li, X., Stefani, E., Zhang, J., Jones, R.C., Thyparambil, S., Wang, G.W., Qiao, X., Bardag-Gorce, F., Ping, P. (2006) Mapping the Murine Cardiac 26S Proteasome Complexes. Circulation Research 99:362-71.

    Zong, C., Gomes, A.V. Drews, O., Li, X., Young, G.W., Berhane, B., Qiao, X., French, S.W., Bardag-Gorce, F., Ping, P. (2006) Regulation of Murine Cardiac 20S Proteasomes: Role of Associating Partners. Circulation Research 99:372-80.

    Gomes, A.V. Zong, C., Ping, P. (2006) Protein Degradation by the 26S Proteasome System in the Normal and Stressed Myocardium. Antioxidants & Redox Signaling 9/10:1677-1691.

    Gomes, A.V. et al., (2005) Murine Cardiac 26S Proteasome: An Organelle Awaiting Exploration. Ann N Y Acad Sci. 1047, 197-207.

    Barnes, J.A,, Singh, S., Gomes, A.V. (2005) Protease activated receptors in cardiovascular function and disease. Mol. Cell Biochem. 263, 227-39.

    Barnes, J.A,, Gomes, A.V. (2002) Proteolytic signals in the primary structure of annexins. Mol. Cell Biochem. 231, 1-7.

    Cuervo A.M., Gomes A.V., Barnes J.A., Dice J.F. (2000) Selective Degradation of Annexins by Chaperone-mediated Autophagy. J. Biol. Chem. 275, 33329-33335.

    Role of Troponins in Muscle Contraction and Disease

    Lounes, K.C., Demeler, B., Anderson, D.E., Gomes, A.V., Potter, J.D., Nassar, R., Anderson, P.A. (2008) Cardiac troponin T forms a tetramer in vitro. Biochemistry. 47, 1970-6.

    Wen Y, Pinto JR, Gomes AV, Xu Y, Wang Y, Wang Y, Potter JD, Kerrick WG. (2008) Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice. J Biol Chem. 283:20484-94

    Gomes, A.V., Liang, J., Potter J.D. (2005). Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development. J. Biol Chem. 280, 30909-15.

    Gomes, A.V., Harada, K., Potter J.D. (2005). A Hypertrophic Cardiomyopathy Mutation in the N-terminal of Troponin I affects the Calcium-Sensitivity, Phosphorylation Kinetics and Proteolytic Susceptibility of Troponin. J. Mol. Cell. Cardiol. 39, 754-65.

    Venkatraman, G., Gomes, A.V., Kerrick, W.G., Potter J.D. (2005) Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform. J. Biol Chem. 280, 17584-92.

    Gomes, A.V., Venkatraman, G., Potter, J.D. (2005) The miscommunicative cardiac cell: when good proteins go bad. Ann N Y Acad Sci. 1047, 30-7.

    Gomes, A.V., Venkatraman, G., Davis, J.P., Tikunova, S.B., Engel, P., Solaro, R.J., Potter J.D. (2004) Cardiac troponin T isoforms affect the Calcium sensitivity of force development in the presence of slow skeletal troponin I: Insights into the role of troponin T isoforms in the fetal heart. J. Biol Chem. 279, 49579-87.

    Venkatraman, G., Harada K., Gomes, A.V., Kerrick, W.G., Potter, J.D. (2003) Different functional properties of troponin T mutants that cause dilated cardiomyopathy. J. Biol Chem. 278, 41670-6.

    Gomes, A.V., Guzman, G., Zhao, J., Potter, J.D. (2002) Cardiac troponin T isoforms affect the Calcium-sensitivity and inhibition of force development: insights into the role of troponin T isoforms in the heart. J. Biol Chem. 277, 35341-35349.

    Lang, R., Gomes, A.V., Zhao, J., Housmans, P.R., Miller, T., Potter, J.D. (2002) Functional Analysis of a Troponin I (R145G) Mutation Associated with Familial Hypertrophic Cardiomyopathy. J. Biol. Chem. 277, 11670-11678.

    Miller, T., Szczesna, D., Housmans, P.R., Zhao, J., de Freitas, F., Gomes, A.V., Culbreath, L., McCue, J., Wang, Y., Xu, Y., Kerrick, W.G. and Potter, J.D. (2001) Abnormal Contractile Function in Transgenic Mice Expressing an FHC-Linked Troponin T (I79N) Mutation. J. Biol. Chem. 276, 3743-3755.

    Szczesna, D., Ghosh, D., Li, Q., Gomes, A.V., Guzman, G., Arana, C., Zhi, G., Stull, J.T., Potter, J.D.(2001) Abnormal Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Calcium binding and phosphorylation. J. Biol. Chem. 276, 7086-7092.