Andrew J. Fisher

Andrew Fisher

Position Title

  • Department of Molecular and Cellular Biology, College of Biological Sciences;
  • Department of Chemistry, College of Letters and Science
4A Briggs Hall

Research Interests

Mechanistic Structural Biochemistry

Systems of focus include: Sulfate activation, RNA Editing, Glycochemistry & Plant Immunity.

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Biophysics
  • Chemistry

Specialties / Focus

  • Biochemistry
  • Biochemistry and Molecular Recognition
  • RNA
  • Structural Biology
  • Structural Biology, Membranes and Macromolecular Assembly


  • Che 107A: Physical Chemistry for the Life Sciences, (Fall)
  • Che 217: X-ray Crystal Structure Determination, (Spring)


  • Fisher Lab Website
    • Postdoc
      • Vandana Gaded
    • Graduate Students
      • Xander Wilcox
      • Samantha Hartanto
      • Alexander Thuy-Boun
    • Undergraduate Students
      • Jessamine Dandan
      • Macy Ha
      • Kimberly Maldonado
      • Abdulsamad Mohammed
      • Cao Nguyen



Unger, E. K., Keller, J. P., Altermatt, M., Liang, R., Matsui, A., Dong, C., Hon, O. J., Yao, Z., Sun, J., Banala, S., Flanigan, M. E., Jaffe, D. A., Hartanto, S., Carlen, J., Mizuno, G. O., Borden, P. M., Shivange, A. V., Cameron, L. P., Sinning, S., Underhill, S. M., Olson, D. E., Amara, S. G., Temple Lang, D., Rudnick, G., Marvin, J. S., Lavis, L. D., Lester, H. A., Alvarez, V. A., Fisher, A. J., Prescher, J. A., Kash, T. L., Yarov-Yarovoy, V., Gradinaru, V., Looger, L. L., and Tian, L. (2020). Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.  Cell.  In Press

Hurlburt, N. K., Guan, J., Ong, H., Yu, H., Chen, X., and Fisher, A. J. (2020). Structural characterization of a non-hydrolyzing UDP-GlcNAc 2-epimerase from Neisseria meningitidis serogroup A. Acta Crystallographica Section F, 76:557-567.

Moreno, M. V., Rockwell, N. C., Mora, M., Fisher, A. J., and Lagarias, J. C. (2020). A far-red cyanobacteriochrome lineage specific for verdins. Proc. Natl. Acad. Sci. U.S.A., 117:27962-27970.

Matthews, M. M., McArthur, J. B., Li, Y., Yu, H., Chen, X., Fisher, A. J. (2020). Catalytic cycle of Neisseria meningitidis CMP-sialic acid synthetase illustrated by high-resolution protein crystallography. Biochemistry59:3157-3168. [PDF Reprint]

Thuy-Boun, A. S., Thomas, J. M., Grajo, H. L., Palumbo, C. M., Park, S., Nguyen, L. T., Fisher, A. J., and Beal, P. A. (2020). Asymmetric Dimerization of Adenosine Deaminase acting on RNA Facilitates Substrate Recognition. Nucleic Acids Res.  48:7958-7972. [PDF Reprint]

Li, Y., Li, R., Yu, H., Sheng, X., Wang, J., Fisher, A. J., Chen, X. (2020). Enterococcus faecalis α1–2-mannosidase (EfMan-I): an efficient catalyst for glycoprotein N-glycan modification. FEBS Letters. 594:439-451. [PDF Reprint]

Monteleone, L. R., Matthews, M. M., Palumbo, C. M., Thomas, J. M., Zheng, Y., Chiang, Y, Fisher, A., J., and Beal, P. A. (2019). A bump-hole approach for directed RNA editing. Cell Chem. Biol. 26:269-277. [PDF Reprint]

Hurlburt, N. K., Chen, L. H., Stergiopoulos, I., and Fisher, A. J. (2018). Structure of the Cladosporium fulvum Avr4 effector in complex with (GlcNAc)6 reveals the ligand-binding mechanism and uncouples its intrinsic function from recognition by the Cf-4 resistance protein. PLoS Pathog. 14(8):e1007263. [PDF Reprint]

Fisher, A. J., and Beal, P. A. (2018). Structural basis for eukaryotic mRNA modification. Curr. Opin. Struct. Biol. 53:59-68. [PDF Reprint]

McArthur, J. B., Yu, H., Tasnima, N., Lee, C. M., Fisher, A. J., and Chen, X. (2018). α2-6-Neosialidase: A sialyltransferase mutant as a sialyl linkage-specific sialidase. ACS Chemical Biology 13:1228-1234. [PDF Reprint]