Andrew J. Fisher

Andrew Fisher

Position Title

Department of Molecular and Cellular Biology, College of Biological Sciences;
Department of Chemistry, College of Letters and Science

4A Briggs Hall

Research Interests

Mechanistic Structural Biochemistry

Systems of focus include: Sulfate activation, RNA Editing, Glycochemistry & Plant Immunity.

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Biophysics
  • Chemistry

Specialties / Focus

  • Biochemistry
  • Biochemistry and Molecular Recognition
  • RNA
  • Structural Biology
  • Structural Biology, Membranes and Macromolecular Assembly


  • Che 107A: Physical Chemistry for the Life Sciences, (Fall)
  • Che 217: X-ray Crystal Structure Determination, (Spring)


  • Fisher Lab Website
    • Postdoc
      • Vandana Gaded
    • Graduate Students
      • Xander Wilcox
      • Samantha Hartanto
      • Alexander Thuy-Boun
    • Undergraduate Students
      • Jessamine Dandan
      • Macy Ha
      • Kimberly Maldonado
      • Abdulsamad Mohammed
      • Cao Nguyen



Monteleone, L. R., Matthews, M. M., Palumbo, C. M., Thomas, J. M., Zheng, Y., Chiang, Y, Fisher, A., J., and Beal, P. A. (2019). A bump-hole approach for directed RNA editing. Cell Chem. Biol26:269-277. [PDF Reprint]

Hurlburt, N. K., Chen, L. H., Stergiopoulos, I., and Fisher, A. J. (2018). Structure of the Cladosporium fulvum Avr4 effector in complex with (GlcNAc)6 reveals the ligand-binding mechanism and uncouples its intrinsic function from recognition by the Cf-4 resistance protein. PLoS Pathog14(8):e1007263. [PDF Reprint]

Fisher, A. J., and Beal, P. A. (2018). Structural basis for eukaryotic mRNA modification. Curr. Opin. Struct. Biol53:59-68. [PDF Reprint]

McArthur, J. B., Yu, H., Tasnima, N., Lee, C. M., Fisher, A. J., and Chen, X. (2018). α2-6-Neosialidase: A sialyltransferase mutant as a sialyl linkage-specific sialidase. ACS Chemical Biology. 13:1228-1234. [PDF Reprint]

Lal, N. K., Nagalakshmi, U., Hurlburt, N. K., Flores, R., Bak, A., Sone, P., Ma, X., Song, G., Walley, J., Shan, L., He, P., Casteel, C., Fisher, A. J., Dinesh-Kumar, S. P. (2018). Nuclear role of a plant receptor-like cytoplasmic kinase in hormone regulation during innate immunity. Cell & Host Microbe. 23:485-497.  [PDF Reprint]

Suter, S. R., Ball-Jones, A., Mumbleau, M. M., Valenzuela, R., Ibarra-Soza, J., Owens, H., Fisher, A. J., and Beal, P. A. (2017). Controlling miRNA-like Off-target Effects of an siRNA with Nucleobase Modifications. Org. Biomol. Chem. 15:10029-10036. [PDF Reprint]

Fisher, A. J., and Beal, P. A. (2017). Effects of Aicardi-Goutières Syndrome Mutations Predicted from ADAR-RNA Structures. RNA Biology14:164-170. [PDF Reprint]

*Matthews, M. M., *Thomas, J. M., Zheng, Y., Tran, K., Phelps, K. J., Scott, A. I., Havel, J., Fisher, A. J., and Beal, P. A. (2016). Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat. Struct. Mol. Biol. 23:426-433. [PDF Reprint] (*Authors contributed equally)