Andrew J. Fisher

Andrew Fisher

Position Title

Department of Molecular and Cellular Biology, College of Biological Sciences
Department of Chemistry, College of Letters and Science

4A Briggs Hall

Research Interests

Mechanistic Structural Biochemistry

Systems of focus include: Sulfate activation, RNA Editing, Glycochemistry & Plant Immunity.

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Biophysics
  • Chemistry

Specialties / Focus

  • Biochemistry
  • Biochemistry and Molecular Recognition
  • RNA
  • Structural Biology
  • Structural Biology, Membranes and Macromolecular Assembly


  • Che 107A Physical Chemistry for the Life Sciences, (Fall)
  • Che 217 X-ray Crystal Structure Determination, (Spring, even years)
  • Che 2C General Chemistry, (Spring, odd years)


  • Fisher Lab
    • Anna Erickson, Nick Hurlburt, Melissa Matthews, Elizabeth Bucher, Gloria Pai, Christine Do

Field Sites

  • Stanford Synchrotron


  • 1987 B.S., Biochemistry Purdue University,
  • 1992 Ph.D., Biophysics Purdue University,


Kohler, A.C., Chen, L.H., Hurlburt, N., Salvucci, A., Schwessinger, B., Fisher, A.J., Stergiopoulos, I. (2016). Structural analysis of an Avr4 effector ortholog offers insight into chitin-binding and recognition by the Cf-4 receptor. Plant Cell. 28:1945-1965. [PDF Reprint]

*Matthews, M. M., *Thomas, J. M., Zheng, Y., Tran, K., Phelps, K. J., Scott, A. I., Havel, J., Fisher, A. J., and Beal, P. A. (2016). Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat. Struct. Mol. Biol. 23:426-433. [PDF Reprint] (*Authors contributed equally)

Erickson, A. I., Sarsam, R. D., and Fisher, A. J. (2015) Structures of Mycobacterium tuberculosis CysQ, with substrate and products bound. Biochemistry 54:6830-6841. [PDF Reprint]

Phelps, K., Ibarra-Soza, J. M., Zheng, Y., Fisher, A. J., Beal, P. A. (2014). Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA. ACS Chemical Biology, 9:1780-1787. [PDF Reprint]

Erickson, A. I., Sarsam, R. D., and Fisher, A. J. (2014) Expression, purification and preliminary crystallographic analysis of Mycobacterium tuberculosis CysQ, a phosphatase involved in sulfur metabolism. Acta Cryst. F70:747-749 [PDF Reprint]

Huynh, N., Aye, A., Li, Y., Yu, H., Cao, H., Tiwari, V. K., Shin, D.-W., Chen, X., and Fisher, A. J. (2013). Structural basis for substrate specificity and mechanism of N-acetyl-D-neuraminic acid lyase from Pasteurella multocida. Biochemistry 52:8570-8579. [PDF Reprint]

Addington, T. A., Mertz, R. W., Siegel, J. B., Thompson, J. M., Fisher, A. J., Filkov, V., Fleischman, N., Suen, A., Zhang, C., Michael D. Toney, M. D. (2013). JANUS: Prediction and Ranking of Mutations Required for Functional Interconversion of Enzymes. J. Mol. Biol. 425:1378-1389. [PDF Reprint]

Sugiarto, G., Lau, K., Qu, J., Li, Y., Lim, S., Mu, S., Ames, J. B., Fisher, A. J. , and Chen, X. (2012). A Sialyltransferase Mutant with Decreased Donor Hydrolysis and Reduced Sialidase Activities for Direct Sialylating Lewisx. ACS Chem. Biol. 7:1232-1240. [PDF Reprint]

Griswold, W. R., Castro, J. N., Fisher, A. J., and Toney, M. D. (2012). Ground-State Electronic Destabilization via Hyperconjugation in Aspartate Aminotransferase. J. Am. Chem. Soc. 134:8436-8438. [PDF Reprint]

Griswold, W. R., Fisher, A. J., and Toney, M. D. (2011). Crystal Structure of Aspartate Aminotransferase Reconstituted with 1-Deazapyridoxal 5’-Phosphate: Internal Aldimine and Stable L-Aspartate External Aldimine. Biochemistry 50:5918-5924. [PDF Reprint]

Kohler, A. C., Gae, D. D., Richley M. A., Stoll S., Gunn, A., Sunghyuk Lim S., Martin S. S., Tzanko I. Doukov T. I., Britt, R. D., Ames, J. B., Lagarias, J. C., and Fisher, A. J. (2010). Structural basis for hydration dynamics in radical stabilization of bilin reductase mutants. Biochemistry 49:6206-6218. [PDF Reprint]

Stoll, S., Gunn, A., Brynda, M., Sughrue, W., Kohler, A. C., Ozarowski, A., Fisher, A. J., Lagarias, J. C., Britt, R. D. (2009). The structure of the biliverdin radical intermediate in phycocyanobilin:ferredoxin oxidoreductase identified by high-field EPR and DFT. J. Am. Chem. Soc. 131:1986-1995. [PDF Reprint]

Gay, S. C., Segel, I. H., and Fisher, A. J. (2009). Crystal structure of the two-domain, hexameric APS kinase from Thiobacillus denitrificans: structural basis for the absence of ATP sulfurylase activity. Acta Crystallogr. D Biol. Crystallogr. 65:1021-1031. [PDF Reprint]

Yu, Z, Lemongello, D., Segel, I. H., and Fisher, A. J. (2008). Crystal structure of Saccharomyces cerevisiae 3'-Phosphoadenosine-5'-phosphosulfate Reductase complexed with adenosine 3',5'-bisphosphate. Biochemistry. 47:12777–12786. [PDF Reprint]