Chang-il Hwang

Chang-il Hwang

Position Title
Assistant Professor

Department of Microbiology and Molecular Genetics, College of Biological Sciences

241B Briggs Hall

Research Interests

Genetic and Epigenetic Alterations in Pancreatic Cancer Progression

The Hwang lab studies how genetic and epigenetic alterations contribute to pancreatic cancer progression, and exploits epigenetic vulnerabilities in cancer therapeutics. Dr. Hwang has established pancreatic organoid models of human and mouse pancreatic cancer and utilized these models for understanding epigenetic landscape of disease progression.

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology (BMCDB)
  • Integrative Genetics and Genomics (IGG)


  • Animal Genomics
  • Cancer Biology
  • Epigenomics
  • Genomics, Proteomics and Metabolomics
  • Gene Regulation
  • Human Genetics and Genomics
  • Model Organism Genetics


  • MIC175 Biology of Cancer
  • BIS10


  • Ph.D., Cornell University, Ithaca, NY
  • M.S., Seoul National University, Seoul, South Korea
  • D.V.M., Seoul National University, Seoul, South Korea


  • The NCI Transition Career Development Award (K22)
  • Ruth L. Kirschstein National Research Service Award (NRSA) F32 Postdoctoral Fellowship Award
  • New York Korean Biologists (NYKB) Award


Ponz-Sarvise, M., Corbo, V., Tiriac, H., Engle, D.D., Frese, K.K., Oni, T.E., Hwang, C.I., Öhlund, D., Chio, I.I.C., Baker, L.A., et al. (2019). Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer. Clin Cancer Res. 2019 Sep 6. pii: clincanres.1398.2019. doi: 10.1158/1078-0432.CCR-19-1398. [Epub ahead of print]

*Roe J.-S., *Hwang, C.-I., Somerville, T.D.D., Milazzo, J.P., Lee, E.J., Da Silva, B., Maiorino, L., Tiriac, H., Young, C.M., Miyabayashi, K., et al. (2017). Enhancer reprogramming promotes pancreatic cancer metastasis. Cell. Aug 24;170(5):875-888.e20. doi: 10.1016/j.cell.2017.07.007. Epub 2017 Jul 27. * Equal contribution.

Ölund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A.S., Ponz-Sarvise, M., Corbo, V., Oni, T., Hearn, S.A., Lee, E.J., Chio, I.I.C., Hwang, C.-I., et al. (2017). Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med. Mar 6;214(3):579-596. doi: 10.1084/jem.20162024. Epub 2017 Feb 23.

*Hwang, C.-I., *Boj, S.F., Clevers, H., Tuveson, D.A. (2016). Preclinical models of pancreatic ductal adenocarcinoma. J Pathol. 238(2);197-204. * Equal contribution.

*Boj, S.F., *Hwang, C.-I.,  Baker, L.A., Engle, D.D., Tuveson, D.A., Clevers, H. (2015). Model organoids provide new research opportunities for ductal pancreatic cancer. Mol Cell Oncol. 23;3(1):e1014757. * Equal contribution.

*Boj, S.F., *Hwang, C.-I., *Baker, L.A., *Chio, I.I.C., *Engle, D.E., *Corbo, V., *Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M., et al. (2015). Organoid Models of Human and Mouse Pancreatic Cancer. Cell. 15;160(1-2):324-38. * Equal contribution.

Cheng, C.Y., Hwang, C.-I., Corney, D.C., Flesken-Nikitin, A., Jiang, L., Öner, G.M., Munroe, R.J., Schimenti, J.C., Hermeking, H., Nikitin, A.Y. (2014). miR-34 Cooperates with p53 in Suppression of Prostate Cancer by Joint Regulation of Stem Cell Compartment. Cell reports. 6, 1000-1007.

Flesken-Nikitin, A., Hwang, C.-I., Cheng, C.Y., Michurina, T.V., Enikolopov, G., and Nikitin, A.Y. (2013). Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. Nature 495, 241-245.

Gu, X., Vedvyas, Y., Chen, X., Kaushik, T., Hwang, C.-I., Hu, X., Nikitin, A.Y., Jin, MM. (2012). Novel strategy for selection of monoclonal antibodies against highly conserved antigens : phage library panning against ephrin-B2 displayed in yeast. Plos One. 7, e30680.

Hwang, C.-I., Choi, J., Zhou, Z., Flesken-Nikitin, A., Tarakhovsky, A., and Nikitin, A.Y. (2011). MET-dependent cancer invasion may be preprogrammed by early alterations of p53-regulated feedforward loop and triggered by stromal cell-derived HGF. Cell Cycle 10, 3834-3840.

Hwang, C.-I., Matoso, A., Corney, D.C., Flesken-Nikitin, A., Körner, S., Wang, W., Boccaccio, C., Thorgeirsson, S.S., Comoglio, P.M., Hermeking, H., et al. (2011). Wild-type p53 controls cell motility and invasion through dual regulation of MET expression. Proc Natl Acad Sci U S A 108, 14240-14245.

*Corney, D.C., *Hwang, C.-I.,  Matoso, A., Vogt, M., Flesken-Nikitin, A., Godwin, A.K., Kamat, A.A., Sood, A.K., Ellenson, L.H., Hermeking, H., et al. (2010). Frequent downregulation of miR-34 family in human ovarian cancers. Clin Cancer Res 16, 1119-1128. *Equal contribution.

Lee, H.-Y., Youn, S.-W., Kim, J.-Y., Park, K.-W., Hwang, C.-I., Park, W.-Y., Oh, B.-H., Park, Y.-B., Walsh, K., Seo, J.-S., et al. (2008). FOXO3a Turns the Tumor Necrosis Factor Receptor Signaling Towards Apoptosis Through Reciprocal Regulation of c-Jun N-Terminal Kinase and NF-{kappa}B. Arterioscler Thromb Vasc Biol 28, 112-120.

Kim, S.-H., Hwang, C.-I., Juhnn, Y.-S., Lee, J.-H., Park, W.-Y., and Song, Y.-S. (2007). GADD153 mediates celecoxib-induced apoptosis in cervical cancer cells. Carcinogenesis 28, 223-231.

Kang, M.-J., Chung, Y.H., Hwang, C.-I., Murata, M., Fugimoto, T., Mook-Jung, I.-H., Cha, C.I., and Park, W.-Y. (2006). Caveolin-1 upregulation in senescent neurons alters amyloid precurosr protein processing. Exp Mol Med 38, 126-133.

Lee, M.S., Jun, D.-H., Hwang, C.-I., Park, S.S., Kang, J.J., Park, H.-S., Kim, J., Kim, J.H., Seo, J.-S., and Park, W.-Y. (2006). Selection of Neural Differentiation-Specific Genes by Comparing Profiles of Random Differentiation. Stem Cells 24, 1946-1955.

Kim, J.H., Ha, I.-S., Hwang, C.-I., Lee, Y.-J., Kim, J., Yang, S.-H., Kim, Y.S., Cao, Y.A., Choi, S., and Park, W.-Y. (2004). Gene expression profiling of anti-GBM glomerulonephritis model: The role of NF-[kappa]B in immune complex kidney disease. Kidney Int 66, 1826-1837.

Seol, J.Y., Park, K.-H., Hwang, C.-I., Park, W.-Y., Yoo, C.-G., Kim, Y.W., Han, S.K., Shim, Y.-S., and Lee, C.-T. (2003). Adenovirus-TRAIL can overcome TRAIL resistance and induce a bystander effect. Cancer Gene Ther 10, 540-548.

Park, W.-Y., Hwang, C.-I., Im, C.-N., Kang, M.-J., Woo, J.-H., Kim, J.-H., Kim, Y.S., Kim, J.-H., Kim, H., Kim, K.-A., et al. (2002). Identification of radiation-specific responses from gene expression profile. Oncogene 21, 8521-8528.

Park, W.-Y., Hwang, C.-I., Kang, M.-J., Seo, J.Y., Chung, J.H., Kim, Y.S., Lee, J.-H., Kim, H., Kim, K.-A., Yoo, H.-J., et al. (2001). Gene Profile of Replicative Senescence Is Different from Progeria or Elderly Donor. Biochemical and Biophysical Research Communications 282, 934-939.