Department of Molecular and Cellular Biology
The role of the ADAM family, integrins and other proteins in sperm-egg mammalian membrane adhesion and membrane fusion. Sperm membrane polarity and protein-protein interactions during spermatogenesis. A variety of approaches are used including mouse genetics (knockouts and transgenics), molecular biology and protein biochemistry.
- 1968 BA Botany University of California, Berkeley
- 1973 PhD Botany University of California, Berkeley
Cho, C., Bunch, D.O., Faure, J.-E., Goulding, E.H., Eddy, E.M., Primakoff, P. and Myles, D.G.. 1998. Fertilization defects in sperm from mice lacking fertilin . Science. 281 :1857-59.
Primakoff, P and D.G. Myles. 2000. The ADAM gene family: Surface proteins with adhesion and protease activity. Trends Genet.. 16:83-87
Miller, B., Georges-Labouesse, E., Primakoff, P. and Myles, D.G.. 2000. Normal fertilization occurs in eggs lacking the integrin 6 1 and is CD9-dependent.. J. Cell Biol. . 149: 1289-1295.