Irwin H. Segel

Irwin Segel

Position Title
Professor Emeritus

25A Briggs Hall

Research Interests

Enzymology, physiology, and regulation of sulfur metabolism with emphasis on the enzymes of inorganic sulfate activation in fungi, plants, animals, and bacteria. Enzymes of thermophilic fungi

Grad Group Affiliations

  • Microbiology


  • 1957 BS Chemistry Rensselaer Polytechnic Institute, New York
  • 1960 MS Biochemistry University of Wisconsin
  • 1962 PhD Biochemistry University of Wisconsin


MacRae I. J., Segel, I. H., and Fisher, A. J.. 2000. Crystal Structure of APS Kinase from Penicillium chrysogenum.. Biochemistry. 39:1613 - 1621

MacRae, I. J., Hanna, E., Ho, J. D., Fisher, A. J., and Segel, I. H. . 2000. Induction of positive cooperativity by amino acid replacements within the C-terminal domain of P. chrysogenum ATP sulfurylase.. Journal of Biological Chemistry. 275:36303-36310

MacRae, I., A. B. Rose, and Segel, I. H.. 1998. Adenosine 5'-Phosphosulfate (APS) Kinase from Penicllium chrysogenum: Site Directed Mutagenesis Studies on Putative Phosphoryl-Accepting and ATP P - Loop residues. . Journal of Biological Chemistry. 273: