Department of Molecular and Cellular Biology
Coastal and Marine Sciences Institute
Biochemical and biophysical adaptations in marine invertebrates; intracellular organization of "soluble" enzymes and other macromolecules not strongly bound to cell ultrastructure; stress proteins and molecular chaperones, primarily in invertebrates.
Specialties / Focus
- Cellular Responses to Toxins and Stress
- NPB 141 Physiological Adaptations of Marine Organisms, Spring
- NPB 141P Advanced Laboratory Topics, Spring
Honors and Awards
- Fulbright Senior Research Fellow, University of London, UK, and Ghent University, Belgium
- Fellow of the AAAS
- Phi Beta Kappa
- Woodrow Wilson Fellow
- Biophysical Society; AAAS; American Society for Cell Biology; Soc. Integr. Compar. Biol. (Comp. Biochem. Physiol.); Soc. Cryobiology; Cell Stress Society International
- 1958 BS Zoology Pennsylvania State University
- 1961 PhD Biology The Johns Hopkins University
Warner, A.H., R.T. Brunet, T.H. MacRae and J.S. Clegg. 2004. Artemin is an RNA- binding protein with high thermal stability and potential RNA chaperone activity. Arch. Biochem. Biophys. 424:189-200.
Qiu, Z., R.I. Viner, T.H. MacRae, J.K. Willsie and J.S. Clegg. 2004. A small heat shock protein from Artemia franciscana is phosphorylated at serine 50. Biochim. Biophys. Acta 1700:75-83.
Collins, C.H. and J.S. Clegg. 2004. A small heat shock protein, p26, from the crustacean Artemia protects mammalian cells (Cos-1) against oxidative damage. Cell Biol. Intern. 28:449-455.
Chen T, R Amons, JS Clegg, AH Warner and TH MacRae. 2003. Molecular characterization of artemin and ferritin from Artemia franciscana. European Journal of Biochemistry 270:137-145.
Willsie JK and JS Clegg. 2002 Small heat shock protein p26 associates with nuclear lamins and HSP 70 in nuclei and nuclear matrix fractions from stressed cells. Journal of Cellular Biochemistry 84:601-614.