Department of Molecular and Cellular Biology, College of Biological Sciences
Gene regulation, especially steroid hormone regulation of gene expression in Drosophila. Molecular mechanisms of morphogenesis and differentiation of epithelia during embryogenesis and imaginal disc development at metamorphosis. Steroid hormone role in development and function of the insect immune system. Drosophila developmental biology and developmental genetics. Identification and characterization of steroid biosynthesis pathways in insects.
- Genetics Society of America
- American Society for Cell Biology
- Society for Developmental Biology
- 1976 BS Biochemistry University of California, Davis
- 1981 PhD Biochemistry University of California, San Francisco
Kiger JA, Natzle JE, Green MM. (2001) Hemocytes are essential for wing maturation in Drosophila. Proc Natl Acad Sci 98:10190-10195.
Harris et al. (2003) A deficeincy screen of the major autosomes identifies a gene (matrimony) that is haplo-insufficient for achiasmate segregation in Drosophila oocytes. Genetics 165: 637-652.
Kiger JA, Natzle JE, Kimbrell DA, Paddy MR,Kleinhesselink, K., Green, M.M. (2007) Tissue remodeling during maturation of the Drosophila wing. Developmental Biology 301: 178-191.
Natzle JE, Kiger JA, Green MM (2008) Bursicon signal mutations separate the epithelial-mesenchymal transition from programmed cell death during Drosophila melanogaster wing maturation. Genetics 180: 885-893.
Natzle JE, Daio F, White BW, Kiger JA (2013) The batone mutation of the disco-related gene targets command neurons in the Bursicon signaling network of Drosophila. Submitted to G#
Natzle JE. 1993. Temporal regulation of Drosophila imagined disc morphogenesis: A hierarchy of primary and secondary 20-hydroxy-ecdysone-responsive loci. Developmental Biology. 155:516-532
Chavez VM, Marques G, Delbecque JP, Kobayashi K, Hollingsworth M, Burr J, Natzle JE and MB O'Connor. 2000. The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels. Development 127: 4115-4126.