Position Title
Assistant Professor
Position Title
Assistant Professor
- Molecular and Cellular Biology
1011 Green Hall
Bio
Research Interests
Structural biology of RhoGEF signaling and regulation
Graduate Program Affiliations
Education and Degree(s)
- B.S. in Zoology, Kent State University
- Ph.D. in Structural Biology, University of Cincinnati
- Postdoc in Structural biology, University of Michigan
Publications
- Cash, Jennifer, Chandan, N., Sharma, P., Smrcka, A., and Tesmer, J. (2020) Discovery of Small Molecules that Target the P-Rex1 PIP3-binding Site and Inhibit P-Rex1-dependent Functions in Human Neutrophils. Molecular Pharmacology, 97, 226-236. DOI: 10.1124/mol.119.117556
- Cash, Jennifer, Urata, S., Li, S., Ravala, S., Avramova, L., Shost, M., Gutkind, J., Tesmer, J., and Cianfrocco, M. (2019) Cryo-electron Microscopy Structure and Analysis of the P-Rex1–Gbg signaling scaffold. Science Advances 5, eaax8855. DOI: 10.1126/sciadv.aax8855
- Cash, Jennifer, Sharma, P., and Tesmer, J. (2019) Structural and Biochemical Characterization of the Pleckstrin Homology Domain of the RhoGEF P-Rex2 and Its Regulation by PIP3. Journal of Structural Biology: X 1, 100001. DOI: 10.1016/j.yjsbx.2018.100001
- Cash, Jennifer, Davis, E., and Tesmer, J. (2016) Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure 24, 730-740. DOI: 10.1016/j.str.2016.02.022
- Cash JN, Angerman EB, Kirby RJ, Merck L, Seibel WL, Wortman MD, Papoian R, Nelson S, Thompson TB. Development of a small-molecule screening method for inhibitors of cellular response to myostatin and activin A. J Biomol Screen. 2013 Aug;18(7):837-44. doi: 10.1177/1087057113482585. Epub 2013 Mar 29. PubMed PMID: 23543431.