Jennifer Cash

Cash profile picture

Position Title
Assistant Professor

Department of Molecular and Cellular Biology, College of Biological Sciences

Green Hall 1011 (office) & 1107 (lab)

Research Interests

Structural biology of RhoGEF signaling and regulation

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology





Selected Publications

Cash, Jennifer, Chandan, N., Sharma, P., Smrcka, A., and Tesmer, J. (2020) Discovery of Small Molecules that Target the P-Rex1 PIP3-binding Site and Inhibit P-Rex1-dependent Functions in Human Neutrophils. Molecular Pharmacology, 97, 226-236. DOI: 10.1124/mol.119.117556

Cash, Jennifer, Urata, S., Li, S., Ravala, S., Avramova, L., Shost, M., Gutkind, J., Tesmer, J., and Cianfrocco, M. (2019) Cryo-electron Microscopy Structure and Analysis of the P-Rex1–Gbg signaling scaffold. Science Advances 5, eaax8855. DOI:  10.1126/sciadv.aax8855

Cash, Jennifer, Sharma, P., and Tesmer, J. (2019) Structural and Biochemical Characterization of the Pleckstrin Homology Domain of the RhoGEF P-Rex2 and Its Regulation by PIP3. Journal of Structural Biology:  X 1, 100001. DOI:  10.1016/j.yjsbx.2018.100001

Cash, Jennifer, Davis, E., and Tesmer, J. (2016) Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure 24, 730-740. DOI: 10.1016/j.str.2016.02.022

Education and Degree(s)
  • Postdoc - Structural biology, University of Michigan
  • Ph.D. Structural Biology, University of Cincinnati
  • B.S. Zoology, Kent State University
Honors and Awards
  • 2015-2016 - American Cancer Society Postdoctoral Fellowship
  • 2008-2010 - American Heart Association Predoctoral Fellowship
Membership and Service
  • 2015-present - American Society for Pharmacology and Experimental Therapeutics (ASPET)