John H. Crowe

Position Title
Professor Emeritus

Department of Molecular and Cellular Biology, College of Biological Sciences

Off campus

Profile Introduction

Cellular dehydration and freezing

Research Interests

Cellular dehydration and freezing. Intracellular water's role in maintenance of macromolecular structure and membrane integrity. Current work is on stabilization of mammalian cells during freeze-drying. The first such cells, human platelets, have been successfully freeze-dried and clinical testing is in progress.

Cellular dehydration and freezing

Specialties / Focus

  • Cell and Developmental Biology
  • Cell Biology
  • Cellular Responses to Toxins and Stress


  • 1965 BS Biology and Chemistry Wake Forest College
  • 1970 PhD Biology University of California, Riverside



Bali R, Savino L, Ramirez DA, Tsvetkova NM, Bagatolli L, Tablin F, Crowe JH, Leidy C. 2009. Macroscopic domain formation during cooling in the platelet plasma membrane: an issue of low cholesterol content. Biochim Biophys Acta.788:1229-37. 



Crowe, J.H. 2013. Water, membranes, and life without water. In: Behand, H. (ed.). Water: The Forgotten Molecule. Springer.



Crowe, J.H. 2010. Trehalose as a chemical chaperone: fact and fantasy. Adv. Exp. Biol. Med.  594: 143-158.