Position Title
Professor Emeritus
Position Title
Professor Emeritus
- Molecular and Cellular Biology
Bio
Research Interests
Structure and function of nerve membrane proteins, particularly the nicotinic acetylcholine receptor (nAChR). Effects of membrane lipids on nAChR conformation, ligand binding, and ion permeation.
Education and Degree(s)
- 1968 B.S. in Chemistry, Massachusetts Institute of Technology
- 1973 Ph.D. in Physical Chemistry, Stanford University
Publications
- Lasalde JA, S Tamamizu, Y-H Lee, and MG McNamee. 1999. Alteration in ion channel function of mouse nicotinic acetylcholine receptor by mutations in the M4 transmembrane domain. Journal of Membrane Biology. 170:157-164
- Kim J and MG McNamee. 1998. Topological disposition of Cys222 inthe a subunit of nicotinic acetylcholine receptor analyzed by fluorescence- quenching and electron paramagnetic resonance measurements. Biochemistry. 37:4680-4686
- Tamamizu S, MG McNamee, G Guzman, J Santiago, LV Rojas, and JA Lasalde. 1999. Functional effects of periodic tryptophan substitutions in the alpha M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor. Biochemistry. :(