Research Interests

Microglia are the immune cells of the brain parenchyma. They are constantly sensing and responding to the brain environment. Several microglia states have been detected in neurodegenerative diseases, such as Alzheimer’s disease and Amyotrophic Lateral Sclerosis, each with a specific transcriptomic and proteomic signature suggesting essential roles in diseases. Using human stem cell models and single-cell omics, we aim to identify, track and manipulate microglia states to determine how they become awry in disease and their impact on patients’ symptoms.