Peter B. Armstrong

Peter Armstrong

Position Title
Professor Emeritus

Unit
Department of Molecular and Cellular Biology

3123 Life Sciences Addition
Bio

Research Interests

Tissue morphodynamics

Role of cell-cell and cell-extracellular matrix adhesion in the determination of tissue structure. Cell adhesion to the extracellular matrix: regulation of cell motility and proliferation. Mechanisms of intercellular invasion. Regulation of embryonic morphogenesis. Mode of action of peptide growth factors.

Comparative immunology

Comparative biology of evolutionarily conserved effectors of the innate immune system: a2-macroglobulin & C-reactive protein. Role of the blood clotting system in immunity. Lipopolysaccharide/endotoxin: immune defense against endotoxemia, phylogenetic distribution of lipopolysaccharide.

Specialties / Focus

  • Cell Biology
  • Differentiation, Morphogenesis and Wound Healing

Courses

  • MCB 150 Developmental biology, Fall
  • MCB 252 Cellular Basis of Morphogenesis, Winter
  • MCB 256 Cell and Molecular Basis of Cancer, Fall
  • MCB 258 Seminar in Developmental Biology, Winter
  • MCB 259 Recent Advences in Developmental Biology, Fall,Winter,Spring

Field Sites

  • Marine Biological Laboratory, Woods Hole, MA http://www.mbl.edu

Professional Societies

  • Marine Biological Laboratory, Woods Hole, MA
  • American Society for Cell Biology
  • International Society for Developmental and Comparative Immunology

Degrees

  • 1961 BS Chemistry University of Rochester
  • 1966 PhD Biology The Johns Hopkins University

Publications

Armstrong, P.B . 2015. Comparative biology of the pentraxin protein family, an evolutionarily conserved component of the innate immune system. Int. Rev. Cell Mol. Biol. 316:1-47.

Chaikeeratisak, V., Tassanakajon, A., Armstrong, P.B. 2014 Interaction of pathogenic Vibrio bacteria with the blood clot of the pacific white shrimp, Litopenaeus vannamei. Biol. Bull. 226:102-110.

Armstrong, M.T., Rickles, F., Armstrong, P.B. 2013. Capture of lipopolysaccharide (endotoxin) by the blood clot: a comparative study.  PLOS ONE 8:e80192 available online at http://dx.plos.org/10.1371/journal.pone.0080192

Armstrong, P.B. 2010.  Role of a2-macroglobulin in the immune responses of invertebrates.  Invert. Survival J. 7:165-180.

Shrive, A.K., Burns, I., Chou, H.-T., Stahlberg, H., Armstrong, P.B., and Greenhough, T.J. 2009. Crystal structures of Limulus SAP-like pentraxin reveal two molecular aggregations. J. Mol. Biol. 386:1240-1254.

Harrington, J.M., Chou, H.-T., Gutsmann, T., Gelhaus, C., Stahlberg, H., Leippe, M., and Armstrong, P.B. 2009. Membrane activity of a C-reactive protein. FEBS Lett. 583:1001-1005.

Harrington, J.M., Chou, H-T., Gutsmann, T., Gelhaus, C., Stahlberg, M., Leippe, M., Armstrong, P.B. 2008. Membrane pore-formation by pentraxin proteins from Limulus, the American horseshoe crab. Biochem. J. 413:305-313.

Armstrong, M.T., Turlo, K., Elges, C.J., Dayton, S.M., Lee, J., Armstrong, P.B. 2006. A novel form of wound healing of the embryonic epidermis. Exp. Cell Res. 312:2415-2423.

Armstrong, M.T., Theg, S.M., Braun, N., Wainwright, N., Pardy, R.L., Armstrong, P.B. 2006. Histochemical Evidence for Lipopolysaccharide (Endotoxin) in Eukaryote Chloroplasts. FASEB J. 20:2145-2146 and E1506-E1509.

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