Savithramma Dinesh-Kumar

Savithramma Dinesh-Kumar

Position Title
Department Chair; Professor

Unit
Department of Plant Biology
Genome Center

116A Briggs Hall
Bio

Research Interests

Host-microbe interactions

NLRs and PRRs function in innate immune signaling

Inter-organellar communications

Programmed cell death (PCD)

Autophagy

Virus-host interactions

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Plant Biology

Courses

  • PLP 210 Biochemistry and Mol Biology of Plant-Microbe interactions , Winter - Guest Lecture
  • GGG 210A Advanced Genetic Analysis , Fall - Guest Lecture
  • BIS 104 Cell Biology, Fall
  • MCB 120L Molecular Biology and Biochemistry Laboratory, Fall

Labs

  • Dinesh-Kumar http://dinesh-kumarlab.genomecenter.ucdavis.edu/
    • Ugrappa Nagalakshmi - Research Scientist
    • Neeraj Lal - BMCDB Graduate Student
    • Isaiah Mohr - PBGG Graduate Student
    • Nathan Meier - PBGG Graduate Student
    • Cameron Hatch - PBGG Graduate Student
    • Yongliang Zhang - Visiting Professor, China Agriculture University
    • Xu Tengzhi - Visiting PhD Student-China Agriculture University
    • Pin-Jui (Cindy) Huang - Junior Specialist
    • Gita Mallya-Undergraduate Student
    • Ronni Ponek - Undergraduate Student
    • My Huyen Nguyen-Undergraduate Student
    • Elaine Nguyen - Undergraduate Student
    • Loreena Sims - Undergraduate Student
    • Eric Vuong - High School Student

Honors and Awards

  • 2015-2016 Faculty Research Award, College of Biological Sciences, UC Davis
  • 2010-2011 Semifinalist, HHMI-GBMF Investigator Competition
  • 2002-2003 Junior Faculty Fellowship
  • 2000 Hellman Family Fellowship

    Professional Societies

    • American Society of Plant Biology
    • IS-MPMI
    • AAAS
    • American Phytopathological Society

    Degrees

    • 1994 Ph D Mol Cellular Dev Biol Iowa State University

    Publications

    Lal, N.K., *Nagalakshmi, U., *Hurlburt, N.K., (*contributed equally) Flores, R., Bak, A., Sone, P., Ma, X., Song, G., Walley, J., Shan, L., He, P., Casteel, C., Fisher, A.J., and Dinesh-Kumar, S.P. (2018) The receptor-like cytoplasmic kinase BIK1 localizes to the nucleus and regulates defense hormone expression during plant innate immunity. Cell Host & Microbe 23:485-497. https://www.ncbi.nlm.nih.gov/pubmed/29649442

    Kumar, A.S., Park, E., Nedo, A., Alqarni, A., Ren, L., Hoban, K., Modla, S., McDonald, J.H., Kambhamettu, C., Dinesh-Kumar, S.P. and Caplan, J.L. (2018) Stromule extension along microtubules coordinated with actin-mediated anchoring guides perinuclear chloroplast movement during innate immunity. eLife 7:e23625 doi: 10.7554/eLife.23625.

    Park, E., Lee, H-Y., Woo, J., Choi, D., and Dinesh-Kumar, S.P. (2017) Spatiotemporal monitoring of Pseudomonas effectors via type III secretion using split fluorescent protein fragments. Plant Cell 29:1571-1584. https://www.ncbi.nlm.nih.gov/pubmed/29338837

    Seo, E., Woo, J., Park, E., Bertolani, S., Siegel, J., Choi, D., and Dinesh-Kumar, S.P. (2016) Comparative analyses of ubiquitin-like ATG8 and cysteine protease ATG4 autophagy genes in the plant lineage and cross-kingdom processing of ATG8 by ATG4. Autophagy 12:2054-2068. https://www.ncbi.nlm.nih.gov/pubmed/27540766

    Caplan, J., Kumar, AS., Park, E., Padmanabhan, M., Hoban, K., Modla, S., Czymmek, K., and Dinesh-Kumar, SP. (2015). Chloroplast stromules function during innate immunity. Dev Cell 34:45-57. (Cover Article). https://www.ncbi.nlm.nih.gov/pubmed/26120031

    Ali, Z., Abul-Faraj, A., Li, L., Ghosh, N., Piatek, M., Mahjoub, A., Aouida, M., Piatek, A., Baltes, N., Voytas, D., Dinesh-Kumar, S.P., Mahfouz, M. (2015) Efficient virus-mediated genome editing in plants using the CRISPR/Cas9 system. Mol Plant S1674-2052(15)00162-8. https://www.ncbi.nlm.nih.gov/pubmed/25749112

    Woo J, Park E, and Dinesh-Kumar SP. (2014) Differential processing of Arabidopsis ubiquitin-like Atg8 autophagy proteins by Atg4 cysteine proteases. Proc. Natl. Acad. Sci. 111:863-868. https://www.ncbi.nlm.nih.gov/pubmed/24379391

    Padmanabhan M, Ma S, Burch-Smith T, Czymmek K, Huijser P, and Dinesh-Kumar SP (2013) Novel Positive Regulatory Role for the SPL6 Transcription Factor in the N TIR-NB-LRR Receptor-Mediated Plant Innate Immunity. PLoS Pathogens 9(3):e1003235. https://www.ncbi.nlm.nih.gov/pubmed/23516366

    Ma S, Shah S, Bohnert HJ, Snyder M, Dinesh-Kumar SP. (2013) Incorporating motif analysis into gene co-expression networks reveals novel modular expression pattern and new signaling pathways. PLoS Genetics 9(10): e1003840. https://www.ncbi.nlm.nih.gov/pubmed/24098147

    Hayward, AP and Dinesh-Kumar, SP (2011) What can Plant Autophagy do for an Innate Immune Response? Annu Rev Phytopathol. 49:557-576. https://www.ncbi.nlm.nih.gov/pubmed/21370973

    Zhu X, Caplan JC, Mamillapalli P, Czymmek K, and Dinesh-Kumar SP (2010) Function of endoplasmic reticulum calcium ATPase in innate immunity mediated programmed cell death. EMBO J 29, 1007-1018. https://www.ncbi.nlm.nih.gov/pubmed/20075858

    *Caplan JC, *Zhu X, (contributed equally), Mamillapalli P, Marathe R, Anandalakshmi R, and Dinesh-Kumar SP. (2009) Induced ER-chaperones regulate a receptor-like kinase to mediate anti-viral innate immune response in plants. Cell Host Microbe 6, 457-469. https://www.ncbi.nlm.nih.gov/pubmed/19917500

    Popescu SC, Popescu GV, Bachan S, Zhang Z, Gerstein M, Snyder M, and Dinesh-Kumar SP. (2009) MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays. Genes Dev 23:80-92. https://www.ncbi.nlm.nih.gov/pubmed/19095804

    Caplan JC, Mamillapalli P, Burch-Smith TM, Czymmek K, and Dinesh-Kumar SP. (2008) Chloroplastic protein NRIP1 mediates innate immune receptor recognition of a viral effector. Cell 132:449-462. https://www.ncbi.nlm.nih.gov/pubmed/18267075

    Patel S, and Dinesh-Kumar SP. (2008) Arabidopsis ATG6 is required to limit the pathogen-associated cell death response. Autophagy 4:20-27. https://www.ncbi.nlm.nih.gov/pubmed/17932459

    Burch-Smith TM, Schiff M, Caplan J, Tsao J, Czymmek K, and Dinesh-Kumar SP. (2007) A novel role for the TIR domain in association with pathogen-derived elicitors. PLoS Biol 5:e68:501-514. https://www.ncbi.nlm.nih.gov/pubmed/17298188

    Liu Y, Schiff M, Czymmek K, Talloczy Z, Levine B, Dinesh-Kumar SP. (2005) Autophagy regulates programmed cell death during the plant innate immune response. Cell 121:567-577. https://www.ncbi.nlm.nih.gov/pubmed/15907470

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