Research Core Facilities

Microscopic image of a rat retina

Research-Driven Collaboration

At the Biological Electron Microscopy Facility, researcher Fei Guo calibrates an electron microscope.
At the Biological Electron Microscopy Facility, researcher Fei Guo calibrates an electron microscope which is capable of resolution below 3.5 Å at 40,000x magnification. David Slipher/UC Davis.

The Office of Research Core Facilities Program promotes a world-class research infrastructure at UC Davis that enables scientific excellence, technology development and outstanding innovations for researchers on campus and the scientific community.

The College of Biological Sciences is home to many of these facilities, which collaborate across campus to enhance the aim and support for institutional research. Below is a list of research cores that are affiliated with different areas of our college.

Department of Evolution and Ecology

  • The UCDNA Sequencing Facility can sequence double-stranded and single-stranded templates from purified plasmids, BACs, cosmids, and PCR products. This facility's instruments are capable of processing approximately twelve 96-well plates in a 24-hour period.

Department of Molecular and Cellular Biology

  • The Light Microscopy Imaging Facility utilizes advanced fluorescence microscopy resources which specialize in live cell imaging and super-resolution methods. 
  • The Biological Electron Microscopy Facility encompasses expertise and imaging systems across the spatial resolution scale, from imaging macromolecular assemblies, subcellular organelles and whole-preserved multicellular tissues.

Department of Plant Biology

  • The Research Greenhouses include the Core Greenhouse Complex and the Orchard Park Facility, which support 24 total greenhouses. 

Genome Center

  • The Bioinformatics Core provides expertise and infrastructure for the acquisition, curation, analysis and distribution of large complex biological datasets, with an emphasis on sequence data.
  • The DNA Technologies Core provides Illumina high-throughput sequencing, PacBio long read sequencing, as well as Fludigm EP1 and Illumina BeadArray high throughput SNP genotyping. The DNA Technologies Core further offers many sequencing-associated services such as library preparation and QC, as well as consultations on project design.
  • The Expression Analysis Core offers many RNA sequencing options such as ribosomal RNA-depletion, polyA enrichment, strand-specific sequencing and ultra-low input libraries. 
  • The Metabolomics Core provides untargeted and metabolite target analyses for a wide range of biochemical pathways, covering over 1,200 identified metabolites with validated analytical methods and known mass spectra and retention times. 
  • The Proteomics Core provides state-of-the-art analytical proteomic services with particular emphasis on label-free quantitative proteomic profiling, the analysis of macromolecular complexes, the post-translational modification of their constituents and standard protein identification from complex protein mixtures.
  • The TILLING Core provides mutants for rice, Arabidopsis thaliana, and tomato as well as other species on request. TILLING (Targeting Induced Local Lesions IN Genomes) is a reverse genetic technique that uses chemical mutagenesis to create libraries of mutagenized individuals that are subjected to high-throughput sequencing for discovery of mutations.