Knots are a part of nature. From pocketed headphones to carelessly packed garden hoses, they find ways to manifest in strings and loops. This isn’t just a truth of mathematics; it’s a truth of biology. In fact, DNA molecules can also get tied into knots.
In order to generate energy, our bodies transfer electrons from food—sugars, fats and proteins—to molecular oxygen, which allows our cells to respire and function. Performed by the mitochondrial electron transport chain (ETC), this process creates ATP, the “molecular currency” for energy in the cell. In a Molecular Cell study, Assistant Professor James Letts, Department of Molecular and Cellular Biology, and colleagues reveal further nuances of the ETC.
In a new study appearing in Nature Cell Biology, UC Davis researchers found that tau molecules can congregate together in a novel, reversible way, which appears to be distinct from the irreversible tangle formation observed in neurodegenerative diseases.
Thanks to a roughly 5-year, $850,000 CAREER grant from the National Science Foundation, Assistant Professor Gerald Quon will develop next-generation computational tools that will allow researchers to better understand and analyze single-cell genomic data.
Much like characters in a bank heist, viruses in competitive environments can collaborate for their share of the "score" of successfully co-infecting hosts. But these relationships may change once inside the host cell, according to Assistant Professor Samuel Díaz-Muñoz.
Assistant Professors Kassandra Ori-McKenney and Richard McKenney are spearheading a new iteration of MCB 110Y “iBioseminars in Cellular and Molecular Biology,” a course that combines at-home video lectures, produced by iBiology, with discussion-based classes.
A parasitic amoeba that causes severe gut disease in humans protects itself from attack by biting off pieces of host cells and putting their proteins on its own surface, according to a study by microbiologists at the University of California, Davis.
When he enrolled at UC Davis, student Mackenzie Noon gravitated towards genetics. Today, he's an undergraduate researcher studying cancer at the chromosomal level in the lab of Professor Ken Kaplan, Department of Molecular and Cellular Biology.
Microtubule fibers are hollow rods made of much smaller tubulin subunits that spontaneously assemble at one end of the rod, but exactly how they do this inside the crowded environment of living cells has been a mystery. UC Davis researchers have uncovered the mechanism that puts these blocks in place, illustrated in a new animation.
During oocyte quality control, a decision is made whether each oocyte should continue and join the reserve of eggs or undergo cellular death. New research from Neil Hunter’s laboratory at UC Davis reveals the surprising way that this critical oocyte quality control process works.
With a grant from the National Science Foundation, Assistant Professor Celina Juliano will help develop genomic tools that will promote regenerative research and hopefully increase the number of researchers using Hydra as a model system.
After a long day of teaching and research, biochemists Richard McKenney and Kassandra Ori-McKenney usually find themselves on their patio discussing topics like the cytoskeleton and motor proteins. It’s shop talk for the couple, both assistant professors in the Department of Molecular and Cellular Biology.
It’s been widely reported that investigators got a break in the East Area Rapist/Golden State Killer case when they uploaded a DNA profile to a genealogy database, GEDmatch, and identified relatives of the suspect, Joseph DeAngelo. Did they get lucky, or did they have a good chance of finding him? UC Davis population biologists Graham Coop and M. D. “Doc” Edge have written a nice explainer of the science behind this search.