Distinguished Professor Emerita
Department of Neurobiology, Physiology and Behavior
Department of Physiology and Membrane Biology, School of Medicine
Genetic, neural, and hormonal regulation of energy balance; alterations with obesity/age; current research focuses on mechanisms utilized by mammalian hibernators that result in CNS neuroprotection and survival in extreme environments.
Extracellular signal reception/intracellular signal transduction and uncoupling proteins; physiological changes with obesity/aging; mechanisms of neuroprotection
Grad Group Affiliations
- Molecular, Cellular and Integrative Physiology
- 280 Briggs Hall
- Jock Hamilton, Sat Chu
Honors and Awards
- Academic Senate Distinguished Teaching Award
- Fellow AAAS (American Association for Advancement of Science)
- UC Davis Prize for Teaching and Scholarly Achievement
- UC Presidential Award for Excellence in Fostering Undergraduate Research
- NIH-NIA MERIT Award
- Arthur C. Guyton Physiology Teacher of the year (American Physiological Society)
- President of the Society of Experimental Biology and Medicine
- Helen Cserr Memorial Lecturer
- President of the American Physiological Society
- Bodil M. Schmidt-Nielsen Distinguished Mentor and Scientist Award (American Physiological Society)
- Distinguished Scientist of the Society of Experimental Biology and Medicine
- Roy G. Daggs Award (American Physiological Society)
- College of Biological Sciences Principles of Community Award (lifetime achievement)
- Chancellor's Achievement Award for Diversity and Community
- AAAS Mentor Award for Lifetime Achievement
- Fellow American Physiological Society (inaugural class)
- American Physiological Society (Past President)
- Society for Experimental Biology and Medicine (Past President)
- Federation of American Societies for Experimental Biology (Previously on Board of Directors)
- New York Academy of Sciences
- 0 BS (Zoology) University of Florida
- 0 MS (Zoology) University of Florida
- 0 PhD (Physiology) Emory University
The publications listed below are selected from a total of 192. The entire list can be accessed at: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47809890/?sort=date&direction=ascending
Hamilton, JS, SM Chau, KJ Malins, GG Ibanez, JM Horowitz, BA Horwitz. Syrian hamster neuroplasticity mechanisms fail as temperature declines to 15°C, but histaminergic neuromodulation persists. J Comp Physiol B – under review 2017.
Mikhailova, A, J Mack, N Vitagliano, JS Hamilton, JM Horowitz, BA Horwitz. Recovery of Syrian hamster hippocampal signaling following its depression during oxygen-glucose deprivation is enhanced by cold temperatures and by hibernation. Neurosci Lett 621:98-103, 2016.
Sekizawa, S-I, B Horwitz, J Horowitz, C-Y Chen. 2013. Protection of signal processing at low temperature in baroreceptive neurons in the nucelus tractus solitarius of Syrian hamsters, a hibernating species. Am J Physiol Regul, Integr & Comp Physiol, 305 (10) R1153-62.
Horwitz, BA, SM Chau, JS Hamilton, C Song, J Gorgone, M Saenz, JM Horowitz, C-Y Chen. 2013, Temporal relationships of blood pressure, heart rate, baroreflex function and body temperature change over a hibernation bout in Syrian hamsters. Am J Physiol Regul, Integ & Comp Physiol 305 (7): R759-768.
Sekizawa, S-I, JM Horowitz, BA Horwitz, C-Y Chen. 2012. Realignment of signal processing within a sensory brainstem nucleus, the NTS, as brain temperature declines in the Syrian hamster, a hibernating species. J Comp Physiol A (Neuroethol Sens Neural Behav Physiol) 198:367-282.
Arant, RJ, MS Goo, PD Gill, YH Nguyen, KD Watson, JS Hamilton, JM Horowitz, BA Horwitz 2011. Decreasing temperature switches hippocampal function from memory formation to modulation of hibernation bout duration in Syrian hamsters. Am J Physiol Regul, Integr & Comp Physiol 301 (2) R438-47.
McDonald, RB, KM Walker, DB Warman, SM Griffey, CH Warden, JJ Ramsey, BA Horwitz. 2008. Characterization of survival and phenotype throughout the lifespan in UCP2/UCP3 genetically altered mice. Exp Gerontol 43: 1061-68.
Asami, DK, RB McDonald, K Hagopian, BA Horwitz, D Warman, A Hsio, C Warden, JJ Ramsey. 2008. Effect of aging, caoric restriction, and uncoupling protein 3 (UCP3) on mitochondria proton leak in mice. Exp Gerontol 43:1069-76.
Bronson, NW, JP Piro, JS Hamilton, JM Horowitz, & BA Horwitz. 2006. Temperature modifies potentiation but not depotentiation in bidirectional hippocampal plasticity of Syrian hamsters (Mesocricetus auratus). Brain Res 1098: 61-70.
Coppola, JD, BA Horwitz, J Hamilton, JE Blevins, RB McDonald. 2005. Reduced feeding response to muscimol and neuropeptide Y in senescent F344 rats. Am J Physiol Regul, Integr, & Comp 288:R1492-98.
Bronson, NW, JS Hamilton, M. Han, P-A Li, I Hornstra, JM Horowitz, BA Horwitz. 2005. LOXL null mice demonstrate selective dentate structural changes but maintain dentate granule cell and CA1 pyramidel cell potentiation in the hippocampus. Neurosci Let 390: 118-122.
Coppola, JD, BA Horwitz, J Hamilton, RB McDonald. 2004. Expression of Neuropeptide Y1 and Y5 receptors in the hypothelamic paraventricular nucleus of aged Fischer 344 rats. Am J Physiol Regul, Integr, & Comp 287: R69-75.
Ohliger-Frerking P, JM Horowitz, & BA Horwitz. 2003. Serotonergic dorsal raphe neurons from obese zucker rats are hyperexcitable. Neuroscience 120:627-634.
Gabaldon AM, DA Gavel, JS Hamilton, RB McDonald, BA Horwitz. 2003. Norepinephrine release in brown adipose tissue remains robust in cold-exposed senescent Fischer 344 rats. Am J Physiol, Regul, Integ & Comp Physiol 285: R91-R98.
Horvath, TK, S Diano, S Miyamoto, S Barry, S Gatti, D. Alberati, F. Livak, A Lombardi, M Moreno, F Goglia, G Mor, J Hamilton, D Kachinskas, B. Horwitz, & CH Warden. 2002. Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice. Int J Obesity 27: 433-442.
Ohliger-Frerking P, JM Horowitz, & BA Horwitz. 2002. Enhanced adrenergic excitation of serotonergic dorsal Raphe neurons in genetically obese rats. Neurosci Lett. 31: 332:107-112.
Horwitz, BA, CA Blanton and RB McDonald. 2002. Physiologic determinants of the anorexia of aging: Insights from animal studies. Ann Rev Nutr 22:417-438
Blanton, CA, BA Horwitz, JE Blevins, JS Hamilton, EJ Hernandez and RB McDonald. 2001. Reduced feeding responses to neuropeptide Y in senescent Fischer 344 rats. Am J Physioll Regul, Integr, & Comp 280(4):R1052-60
De Fanti BA, DA Gavel, JS Hamilton, and BA Horwitz. 2000. Extracellular hypothalamic serotonin levels after dorsal raphe nuclei stimulation of lean (Fa/Fa) and obese (fa/fa) Zucker rats. Brain Research. 869:6-14